Author

M. Holm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

J. Taunton· 2 shared A. A. Q. Al-Khdhairawi· 1 shared A. Brown· 1 shared A. Ferguson· 1 shared A. Levchenko· 1 shared A. Singhal· 1 shared C. Haglund· 1 shared D. Ruggero· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

J. Taunton

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Solid tumor growth depends on an intricate equilibrium of malignant cell states

S. R. Torborg, O. Grbovic-Huezo, A. Singhal, M. Holm, K. Wu, X. Han, Y.-J. Ho, C. Haglund, M. J. Mitchell, S. W. Lowe, L. E. Dow, K. L. Pitter, F. J. Sanchez-Rivera, A. Levchenko, T. Tammela

This study identifies a stereotypic organization of pancreatic ductal adenocarcinoma cells based on WNT signaling and Notch ligand interactions, showing that disrupting this equilibrium suppresses tumor growth and metastasis.

bioRxiv · Dec 30, 2023 · PreprintCancer Biology

Didemnin B and ternatin-4 inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes

M. F. Juette, J. D. Carelli, E. J. Rundlet, A. Brown, S. Shao, A. Ferguson, M. R. Wasserman, M. Holm, J. Taunton, S. C. Blanchard

This study shows how didemnin B and ternatin-4 inhibit translation by trapping eEF1A in a GTPase-activated conformation using single-molecule imaging and cryo-EM.

bioRxiv · Aug 1, 2022 · PreprintBiochemistry

Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumor eEF1A antagonist SR-A3

H. Wang, H. Yang, M. Holm, K. Oltion, H. Tom, A. A. Q. Al-Khdhairawi, J.-F. F. Weber, S. Blanchard, D. Ruggero, J. Taunton

This study synthesizes and characterizes SR-A3, a stereoisomer of a natural product, showing enhanced binding kinetics and therapeutic efficacy in a mouse lymphoma model.

bioRxiv · Oct 6, 2020Pharmacology & Toxicology