T. Zhou

This study shows iminosugar glucosidase inhibitors suppress SARS-CoV-2 replication in tissue culture and enhance Remdesivir's effect.

A broadly neutralizing antibody protects against multiple SARS-CoV and SARS-CoV-2 variants in mice by targeting a conserved epitope in the receptor-binding domain.

This paper isolates and characterizes nanobodies from camelids and engineered mice that neutralize SARS-CoV-2 variants through conserved epitopes and multimeric avidity.

This study shows that an AS03-adjuvanted SARS-CoV-2 spike protein vaccine induces strong antibody responses and protects nonhuman primates from viral challenge.

The paper identifies ultrapotent antibodies from convalescent donors that neutralize SARS-CoV-2 variants and reduce escape mutant generation.

This study uses high-throughput single-copy sequencing to detect SARS-CoV-2 spike variants during acute COVID-19, revealing genetic adaptation coinciding with humoral immunity.

The paper shows that CSP reduces ATG levels via ubiquitination by NEDD4, enabling EEFs to evade IFN-gamma-mediated killing in hepatocytes.

This study identifies potent SARS-CoV-2 neutralizing antibodies targeting the N-terminal domain (NTD) and reveals they bind a common supersite on the spike protein.

This study identifies a public antibody class, IGHV3-53/3-66, with potent SARS-CoV-2 neutralization capabilities through paired heavy and light chain interactions.

InSegtCone automates the segmentation of crystalline cones in arthropod compound eyes, achieving 60%-80% accuracy and 250x speed compared to manual labeling.

This study identifies altered small RNA modifications in Alzheimer's disease post-mortem samples compared to controls, with specific reductions in certain small RNA types.

This study uses smFRET to observe real-time conformational dynamics of SARS-CoV-2 spikes on virus particles, revealing multiple states and mechanisms of neutralization by antibodies and convalescent plasma.

This study shows that Eng1 and Ywp1 in C. albicans reduce Dectin-1 binding by masking β-glucans, thereby decreasing immune recognition and virulence.

The paper isolates and characterizes 61 SARS-CoV-2-neutralizing monoclonal antibodies from infected patients, identifying potent antibodies targeting multiple epitopes on the spike protein.

This paper uses cryo-EM to show how SARS-CoV-2 spike protein undergoes pH-dependent structural changes that affect ACE2 binding and antibody evasion.

The paper develops biotin-labeled SARS-CoV-2 spike molecular probes using structure-based design and purification methods, achieving high yields and enabling antibody characterization.

This paper develops a nanoparticle platform for displaying trimeric antigens, showing that SARS-CoV-2 spike-LuS nanoparticles induce 25-fold higher neutralizing responses than spike alone.

This study creates a zebrafish model expressing Abcb4 to investigate drug resistance mechanisms, finding that NF-κB plays a central role in regulating Abcb4-mediated resistance.

This study evaluates the in vivo efficacy and PK/PD of KBP-7072, an aminomethylcycline antibiotic, in pneumonia and thigh infection models, showing significant dose-dependent reductions in CFUs and improved survival.

The paper develops a queuing model of stochastic transcription using non-exponential waiting-time distributions to better capture gene expression dynamics and shows that reduced waiting-time noise can increase mRNA noise.

This study shows that IlvE promotes Listeria monocytogenes growth, stress resistance, and virulence by facilitating branched chain fatty acid synthesis and Ile-dependent pathways.

This study identifies NudCL2 as a cochaperone that stabilizes cohesin subunits by modulating Hsp90 ATPase activity, preventing mitotic defects and sister chromatid separation.

This study shows that targeting the HIV-1 fusion peptide with specific immunogens induces cross-clade neutralizing antibodies in animals.