Author

J. F. W. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

K.-Y. Yuen· 5 shared S. Yuan· 3 shared C. Luo· 2 shared H. Chu· 2 shared J.-P. Cai· 2 shared A. Chatterjee· 1 shared A. Garcia-Sastre· 1 shared A. I. Su· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersMicrobiology

K.-Y. Yuen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The SARS-CoV-2 Omicron (B.1.1.529) variant exhibits altered pathogenicity, transmissibility, and fitness in the golden Syrian hamster model

S. Yuan, Z.-W. Ye, R. Liang, K. Tang, A. J. Zhang, G. Lu, C. P. Ong, V. K.-M. Poon, C. C.-S. Chan, B. W. Y. Mok, Z. Qin, Y. Xie, H. Sun, J. O.-L. Tsang, T. T.-T. Yuen, , J. F. W. Chan

The study compares the pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron and Delta variants in golden Syrian hamsters, finding Omicron less pathogenic but more transmissible and capable of outcompeting Delta under immune pressure.

bioRxiv · Jan 12, 2022 · PreprintMicrobiology

A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses

P. Wang, R. G. Casner, M. S. Nair, J. Yu, Y. Guo, M. Wang, J. F. W. Chan, G. Cerutti, S. Iketani, L. Liu, Z. Sheng, Z. Chen, K.-Y. Yuen, P. D. Kwong, Y. Huang, , D. D. Ho

This paper identifies a monoclonal antibody, 2-36, that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses, with a conserved epitope in the RBD identified through cryo-EM.

bioRxiv · Oct 13, 2021Microbiology

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

W. Qiao, H. E. Lau, H. Xie, V. K. M. Poon, C. C. S. Chan, H. Chu, S. Yuan, T. T. T. Yuen, K. K. H. Chik, J. O. L. Tsang, C. C. Y. Chan, J.-P. Cai, C. Luo, K.-Y. Yuen, K. M. C. Cheung, , K. W. K. Yeung

This study shows SARS-CoV-2 infection causes bone loss in golden Syrian hamsters through cytokine dysregulation and osteoclastogenesis.

bioRxiv · Oct 8, 2021Microbiology

A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals

L. Riva, S. Yuan, X. Yin, L. Martin-Sancho, N. Matsunaga, S. Burgstaller, L. Pache, P. De Jesus, M. V. Hull, M. Chang, J. F. W. Chan, J. Cao, V. Kwok-Man Poon, K. Herbert, T.-T. Nguyen, , S. Chanda

This study identifies 30 known drugs that inhibit SARS-CoV-2 replication, with six showing effective concentrations likely to be therapeutic in patients.

bioRxiv · Apr 16, 2020 · PreprintMicrobiology

Replication of MERS and SARS coronaviruses in bat cells offers insights to their ancestral origins

S. Lau, R. Y. Fan, H. K. H. Luk, L. Zhu, J. Fung, K. S. Li, E. Y. M. Wong, S. S. Ahmed, J. F. W. Chan, K.-H. Kok, K.-H. Chan, U. Wernery, K.-y. Yuen, P. C. Y. Woo

This study replicates MERS and SARS coronaviruses in bat cells, finding that DPP4 expression and species-specific factors determine viral susceptibility.

bioRxiv · May 20, 2018Microbiology