Tam Duong

Aging, dauer, and stature phenotypes are conferred by structure-directed missense mutations in the endogenous AGE-1/phosphatidylinositol 3-kinase catalytic subunit.

The paper uses structure-guided CRISPR/Cas9 to study PI3K mutations in C. elegans, revealing a novel Ras>PI3K signaling axis that affects growth, dauer formation, and lifespan.

A single-component optogenetic toolkit for programmable control of microtubule

The paper develops a single-component optogenetic toolkit to control microtubule organization and dynamics in living systems, revealing their role in lysosomal trafficking and ER signaling.

Expanding the Caenorhabditis elegans auxin-inducible degron system toolkit with internal expression and degradation controls and improved modular constructs for CRISPR/Cas9-mediated genome editing

The paper introduces new tools for the auxin-inducible degron system in C. elegans, enabling conditional protein depletion through CRISPR/Cas9-mediated genome editing.

Ral signals through a MAP4 Kinase-p38 MAP kinase cascade in C. elegans cell fate patterning.

The paper identifies a Ral-dependent signaling cascade in C. elegans that transduces lower EGF doses to promote 2° vulval precursor cell fate.