Renalase activates mitochondrial leak metabolism in response to cellular stress and to repair damage after injury
Xiaojia Guo, Rongmin Chen, Christine Shugrue, Fei‐Fei Shang, Rolando García-Milian, Haley Moller, Pawel Licznerski, Tian-min Chen, Richard Glenn Kibbey, Ons M’Saad, Yuan Tian, Joerg Bewersdorf, Frank J. Giordano, Fred S. Gorelick, Robert L. Safirstein, , Gary V. Désir
This paper shows that renalase activates mitochondrial leak metabolism to enhance protein synthesis and protect cells from stress and injury.
bioRxiv · Aug 19, 2025 · PreprintCell Biology