Author

Fred S. Gorelick

Yale Cancer CenterORCID 0000-0001-8293-6803Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

Allison WingiD· 1 shared Andy Tang· 1 shared Christian Felipe RuiziD· 1 shared Christine ShugrueiD· 1 shared Daniel C. McQuaidiD· 1 shared Daniel CanalsiD· 1 shared Elizabeth Ann JonasiD· 1 shared Fei‐Fei ShangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

Allison WingORCID

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2 papers

Recent·Most cited

Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas

Christian Felipe Ruiz, Xiangyu Ge, Rylee McDonnell, Sherry S. Agabiti, Daniel C. McQuaid, Andy Tang, Meera Kharwa, Jennifer Goodell, Rocío del M. Saavedra-Peña, Allison Wing, Guangtao Li, Natasha Pinto-Medici, Marie E. Robert, Rohan Varshney, Michael C. Rudolph, , Mandar Deepak Muzumdar

This study shows that diet-induced changes in phospholipid composition affect ferroptosis sensitivity and tumorigenesis in pancreatic cancer.

Cancer Discovery · Apr 29, 2026Peer-reviewedCancer Biology

Renalase activates mitochondrial leak metabolism in response to cellular stress and to repair damage after injury

Xiaojia Guo, Rongmin Chen, Christine Shugrue, Fei‐Fei Shang, Rolando García-Milian, Haley Moller, Pawel Licznerski, Tian-min Chen, Richard Glenn Kibbey, Ons M’Saad, Yuan Tian, Joerg Bewersdorf, Frank J. Giordano, Fred S. Gorelick, Robert L. Safirstein, , Gary V. Désir

This paper shows that renalase activates mitochondrial leak metabolism to enhance protein synthesis and protect cells from stress and injury.

bioRxiv · Aug 19, 2025 · PreprintCell Biology