Integration of multi-modal measurements identifies critical mechanisms of tuberculosis drug action
William C. Johnson, A. Paul Alivisatos, Trever C. Smith, Nhi Van, Vijay Soni, Joshua B. Wallach, Nicholas A. Clark, Timothy A. Fitzgerald, Joshua J. Whiteley, Shumin Tan, Artem Sokolov, Dale Michael Ando, Dirk Schnappinger, Kyu Young Rhee, Bree B. Aldridge
This study introduces DECIPHAER, a tool that identifies critical mechanisms of tuberculosis drug action by integrating multi-modal data, revealing that respiration inhibition is more impactful than cell wall effects.
Cell Systems · Jul 29, 2025Peer-reviewedMicrobiology