K. R. Levental

Ether lipids influence cancer cell fate by modulating iron uptake

This study shows that ether lipids in cancer cells regulate membrane properties to influence iron uptake, ferroptosis, and metastasis, offering a therapeutic target.

Cell Membranes Sustain Phospholipid Imbalance Via Cholesterol Asymmetry

The paper reveals that mammalian plasma membranes have phospholipid imbalances due to cholesterol asymmetry, affecting membrane permeability and protein localization.

Partitioning to ordered membrane domains regulates the kinetics of secretory traffic

The paper investigates how membrane domains influence secretory traffic kinetics, finding that raft affinity affects Golgi exit rates but not ER exit.

Serinc5 restricts HIV membrane fusion by altering lipid order and heterogeneity in the viral membrane

This study shows Serinc5 restricts HIV infection by altering viral membrane lipid order and heterogeneity, reducing fusion pore formation and infectivity.

Coupling of protein condensates to ordered lipid domains determines functional membrane organization

This study shows that protein condensates and lipid domains couple to organize T-cell membrane function during activation.

Alpha-ketoglutarate inhibits Regulatory T cell differentiation by coupling lipidome remodelling to mitochondrial metabolism

This study shows that alpha-ketoglutarate inhibits regulatory T cell differentiation by altering lipid metabolism and mitochondrial function.

The mammalian plasma membrane is defined by transmembrane asymmetries in lipid unsaturation, leaflet packing, and protein shape

The paper characterizes lipid and protein asymmetries in mammalian plasma membranes and shows their conservation across eukaryotes.

Lipidomic and biophysical homeostasis of mammalian membranes counters dietary lipids perturbations to maintain cellular fitness

The paper shows that mammalian cells counteract dietary lipid perturbations through lipidomic remodeling to maintain membrane physical properties and cellular fitness.