Author

V. Darley-Usmar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

G. Benavides· 2 shared A. Hjelmeland· 1 shared A. Mukherjee· 1 shared A. W. Baguley· 1 shared B. Spurlock· 1 shared D. Chanda· 1 shared D. Kurundkar· 1 shared D. Parker· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersCell Biology

G. Benavides

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Metabolic Derangement in Polycystic Kidney Disease Mouse Models Is Ameliorated by Mitochondrial-Targeted Antioxidants

N. Daneshgar, A. W. Baguley, P.-I. Liang, F. Wu, Y. Chu, M. T. Kinter, G. A. Benavides, M. S. Johnson, V. Darley-Usmar, J. Zhang, K.-S. Chan, D.-F. Dai

This study shows mitochondrial-targeted antioxidants reduce oxidative stress and metabolic issues in PKD mouse models, improving disease progression and restoring metabolic pathways.

bioRxiv · Sep 15, 2021 · PreprintPathology

Mesenchymal Stromal Cell Aging Impairs the Self-Organizing Capacity of Lung Alveolar Epithelial Stem Cells

D. Chanda, M. Rehan, S. R. Smith, K. G. Dsouza, Y. Wang, K. Bernard, D. Kurundkar, V. Memula, K. Kojima, J. A. Mobley, G. Benavides, V. Darley-Usmar, Y.-i. Kim, J. W. Zmijewski, J. Deshane, V. J. Thannickal

This study shows that aging of lung mesenchymal stromal cells impairs the ability of alveolar epithelial stem cells to form 3D organoids, and that reducing Nox4 activity can partially reverse this effect.

bioRxiv · Mar 5, 2021Cell Biology

Oxylipin metabolism is controlled by mitochondrial b-oxidation during bacterial inflammation.

M. Misheva, K. Kotzamanis, L. Davies, V. Tyrrell, P. Rodrigues, G. Benavides, H. Christine, R. Murphy, P. Kennedy, P. Taylor, M. Rosas, S. Jones, J. McLaren, S. Deshpande, R. Andrews, , V. O'Donnell

This study shows that mitochondrial β-oxidation removes oxylipins during bacterial inflammation, with CPT1 playing a key role, and identifies associated genetic upregulation in human sepsis.

bioRxiv · Aug 17, 2020Biochemistry

Mito-SinCe2 Approach to Quantify Relationships between Mitochondrial Dynamics and Energetics status

K. Mitra, B. Spurlock, P. Gupta, M. K. Basu, A. Mukherjee, A. Hjelmeland, V. Darley-Usmar, D. Parker, M. Foxall

The paper develops and validates mito-SinCe2, an approach to quantify the relationship between mitochondrial dynamics and energetics, revealing distinct states and linear relationships in ovarian tumor initiating cells.

bioRxiv · Feb 1, 2019 · PreprintCell Biology