V. Horvath

Control of Molecular Biochemistry and Cell Injury Responses through Highly Ordered Supramolecular Assembly of Flavonoids

Molecular dynamic simulations reveal flavonoids self-assemble into ordered structures that interact with proteins, modulate enzyme activity, and protect cells from UV-induced injury.

Mucus production, host-microbiome interactions, hormone sensitivity, and innate immune responses modeled in human cervix chips

This paper develops human cervical Organ Chip models to study mucus production, host-microbiome interactions, and immune responses, showing they mimic in vivo conditions and respond to microbiome changes.

Population-scale long-read sequencing uncovers transposable elements contributing to gene expression variation and associated with adaptive signatures in Drosophila melanogaster

The paper uses long-read sequencing to analyze transposable element variation in Drosophila melanogaster populations, showing increased detection rates and associations with gene expression and adaptive traits.

Basal and stress-induced expression changes consistent with water loss reduction explain desiccation tolerance of natural Drosophila melanogaster populations

The paper identifies gene expression and physiological differences in Drosophila melanogaster populations that correlate with desiccation tolerance, highlighting the role of tRNA-derived small RNAs in stress response.

Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip

This paper develops a human vagina-on-a-chip model to study vaginal microbiome-host interactions and their effects on health outcomes.

The mechanical regulation of RNA binding protein hnRNPC in the failing heart

The paper shows that hnRNPC upregulation and relocation to the Z-disk in failing hearts affects mRNA alternative splicing and mechanotransduction.

Stress response, behavior, and development are shaped by transposable element-induced mutations in Drosophila

This study identifies transposable element-induced mutations in Drosophila that influence stress response, behavior, and development through genetic analysis of population frequencies and functional effects.