L. Green

BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance

This study identifies secondary splice-site mutations in BRCA1 that drive exon skipping and PARP inhibitor resistance in ovarian and breast cancer.

MYBPC3 D389V Variant Induces Hypercontractility in Cardiac Organoids

This study investigates the molecular mechanisms of HCM caused by the MYBPC3 D389V variant using cardiac organoids and shows hypercontractility and mitochondrial defects that are rescued by a myosin inhibitor.

Detailed Survey of an in-vitro Intestinal Epithelium Model by Single-Cell Transcriptomics

This study uses single-cell RNA sequencing to analyze a Caco-2/HT29 co-culture model, identifying cell types and assessing its similarity to human intestinal epithelium, finding it lacks some transporters and immune markers.

Exploring the potential of using simulation games for engaging with sheep farmers about lameness recognition

This study evaluates a simulation game designed to help sheep farmers recognize lameness, finding no link between game performance and real-life experience but noting potential for future development.

Population-scale long-read sequencing uncovers transposable elements contributing to gene expression variation and associated with adaptive signatures in Drosophila melanogaster

The paper uses long-read sequencing to analyze transposable element variation in Drosophila melanogaster populations, showing increased detection rates and associations with gene expression and adaptive traits.

Basal and stress-induced expression changes consistent with water loss reduction explain desiccation tolerance of natural Drosophila melanogaster populations

The paper identifies gene expression and physiological differences in Drosophila melanogaster populations that correlate with desiccation tolerance, highlighting the role of tRNA-derived small RNAs in stress response.

The genomic basis of copper tolerance in Drosophila is shaped by a complex interplay of regulatory and environmental factors

This study identifies genetic and environmental factors shaping copper tolerance in Drosophila by analyzing natural population variation and functional gene responses.

Increasing Chlorophyll a Amid Stable Nutrient Concentrations in Rhode Island Lakes and Reservoirs

The paper analyzes water quality trends in Rhode Island lakes and reservoirs, finding increasing chlorophyll a despite stable nutrients and temperature's role in primary production.

In vitro reconstitution of branched microtubule nucleation

This study reconstitutes branched microtubule nucleation in vitro using purified Augmin and γ-TuRC from Drosophila embryos, showing their cell cycle-dependent interaction.