Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
11 papers
Recent·Most cited
S. Boopathy, B. E. Luce, C. M. Lugo, P. Hakim, J. L. McDonald, H. L. Kim, J. Ponce, B. Ueberheide, L. H. Chao
This study identifies interaction interfaces between SLC25A46 and mitochondrial fusion proteins Opa1 and Mfn2 using crosslinking mass-spectrometry and AlphaFold 2 modeling.
Journal of Biological Chemistry · Oct 1, 2024Peer-reviewedBiochemistry
T. A. Bell, B. E. Luce, P. Hakim, V. Y. Ananda, H. Dardari, T. H. Nguyen, A. Monshizadeh, L. H. Chao
This study shows that Prom1 and Ttyh1 both induce extracellular vesicle formation, with Ttyh1 producing more tubulated vesicles and showing stronger cholesterol binding.
bioRxiv · Nov 8, 2023Biochemistry
F. M. C. Benning, S. Jenni, C. Y. Garcia, T. H. Nguyen, X. Zhang, L. H. Chao
The paper determines the structure of VP39, a baculovirus capsid protein, revealing its assembly into a helical tube and conserved fold across species.
bioRxiv · Jun 15, 2023Biophysics
M. Y. Fry, P. P. Navarro, P. Hakim, V. Y. Ananda, X. Qin, J. C. Landoni, S. Rath, Z. Inde, C. M. Lugo, B. E. Luce, Y. Ge, J. L. McDonald, I. Ali, L. L. Ha, B. P. Kleinstiver, , L. H. Chao
This study uses cryo-electron tomography to visualize how different Opa1 forms affect mitochondrial cristae architecture and function in mouse cells.
bioRxiv · Jan 16, 2023 · PreprintBiophysics
E. N. Abdulaziz, T. A. Bell, B. Rashid, M. L. Heacock, O. S. Skinner, M. A. Yaseen, L. H. Chao, V. K. Mootha, A. J. Pierik, V. Cracan
This study identifies a unique fusion protein in T. vaginalis that efficiently catalyzes oxygen reduction to water using NADH, providing structural and functional insights into its redox system.
bioRxiv · Feb 2, 2022Biochemistry
P. P. Navarro, A. Vettiger, V. Y. Ananda, P. Montero Llopis, C. Allolio, T. G. Bernhardt, L. H. Chao
This study uses cryo-ET and fluorescence microscopy to analyze E. coli division site architecture and cell wall dynamics, revealing conserved mechanisms across bacterial species.
bioRxiv · Oct 2, 2021 · PreprintMicrobiology
Y. Ge, S. Boopathy, T. H. Nguyen, C. M. Lugo, L. H. Chao
The paper investigates how cardiolipin distribution affects mitochondrial inner membrane fusion mediated by Opa1, finding that cardiolipin in the outer leaflet is crucial for tethering and fusion.
bioRxiv · Sep 1, 2021Biophysics
X. Shi, R. Lingerak, C. Herting, Y. Ge, S. Kim, P. Toth, C. Cuizon, J. Zheng, L. H. Chao, K. Sossey-Alaoui, M. Buck, S. Singh, V. Varadan, J. Himanen, D. Hambardzumyan, , B. Wang
This study identifies molecular interfaces that mediate EphA2 receptor assembly and distinguishes between canonical and noncanonical signaling pathways.
bioRxiv · Apr 11, 2021 · PreprintBiophysics
R. Sloutsky, N. Dziedzic, M. J. Dunn, R. Bates, A. P. Torres-Ocampo, S. Boopathy, B. Page, J. G. Weeks, L. H. Chao, M. M. Stratton
The paper identifies 70 CaMKII transcripts in human hippocampus and shows that the hub domain regulates kinase activity through allosteric interactions.
bioRxiv · Jan 10, 2020Biochemistry
Y. Ge, X. Shi, S. Boopathy, J. McDonald, A. W. Smith, L. H. Chao
The paper shows that two forms of Opa1 work together to regulate mitochondrial inner-membrane fusion, with l-Opa1 enabling docking and s-Opa1 facilitating efficient pore opening.
bioRxiv · Dec 11, 2019Biophysics
L. H. Chao, J. Jang, A. Johnson, A. Nguyen, N. S. Gray, P. L. Yang, S. C. Harrison
The paper studies how small-molecule inhibitors block dengue virus membrane fusion by targeting the envelope protein's conformational change, showing that ~15 bound molecules per particle prevent fusion.
bioRxiv · Jul 9, 2018Biophysics