Author

W. E. Diehl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:metagenomics· 1

Frequent Co-Authors

J. Luban· 5 shared A. Dauphin· 3 shared C. Carbone· 2 shared K. Kim· 2 shared L. Yurkovetskiy· 2 shared P. C. Sabeti· 2 shared S. F. Schaffner· 2 shared S. M. McCauley· 2 shared

Activity by Year

2018-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersMicrobiology

J. Luban

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Author profile →

5 papers

Recent·Most cited

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

L. Yurkovetskiy, X. Wang, K. E. Pascal, C. Tompkins-Tinch, T. Nyalile, Y. Wang, A. Baum, W. E. Diehl, A. Dauphin, C. Carbone, K. Veinotte, S. B. Egri, S. F. Schaffner, J. E. Lemieux, J. Munro, , J. Luban

This study shows the D614G SARS-CoV-2 spike protein variant is more infectious but has reduced ACE2 affinity and altered trimer conformation, affecting viral entry and antibody neutralization.

bioRxiv · Jul 4, 2020Microbiology

Reporter assays for Ebola virus nucleoprotein oligomerization, virion-like particle budding, and minigenome activity reveal the importance of nucleoprotein amino acid position 111

A. E. Lin, W. E. Diehl, Y. Cai, C. L. Finch, C. Akusobi, R. N. Kirchdoerfer, L. Bollinger, S. F. Schaffner, E. A. Brown, E. O. Saphire, K. G. Andersen, J. H. Kuhn, J. Luban, P. C. Sabeti

The paper develops reporter assays to study Ebola virus nucleoprotein (NP) function and finds that amino acid position 111 affects oligomerization, virion budding, and transcription/replication.

bioRxiv · Dec 10, 2019Microbiology

Influence of different glycoproteins and of the virion core on SERINC5 antiviral activity

W. E. Diehl, M. H. Guney, P. P. Kyawe, J. M. White, M. Pizzato, J. Luban

This study investigates how retroviral glycoproteins and cores influence SERINC5 antiviral activity, finding that sensitivity depends on both factors.

bioRxiv · Sep 24, 2019Microbiology

Cyclophilin A protects HIV-1 from restriction by human TRIM5α

K. Kim, A. Dauphin, S. Komurlu, L. Yurkovetskiy, W. E. Diehl, S. M. McCauley, C. Carbone, C. Strambio-De-Castillia, E. M. Campbell, J. Luban

This study shows that Cyclophilin A protects HIV-1 from restriction by human TRIM5α by shielding the viral capsid from early inhibition during infection.

bioRxiv · Aug 24, 2019Microbiology

Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines

S. M. McCauley, K. Kim, A. Nowosielska, A. Dauphin, W. E. Diehl, J. Luban

The paper shows that HIV-1 provirus RNA activates innate immune responses through post-transcriptional elements, suggesting new therapeutic targets.

bioRxiv · Apr 5, 2018Microbiology