Author

A. E. Lin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:scRNA-seq· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1

Frequent Co-Authors

P. C. Sabeti· 2 shared A. K. Shalek· 1 shared A. Ploss· 1 shared B. A. Sellers· 1 shared B. Adamson· 1 shared B. Dighero-Kemp· 1 shared B. Wang· 1 shared C. Aditya· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersMicrobiology

P. C. Sabeti

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Massively-parallel Microbial mRNA Sequencing (M3-Seq) reveals heterogenous behaviors in bacteria at single-cell resolution

B. Wang, A. E. Lin, J. Yuan, M. D. Koch, B. Adamson, N. S. Wingreen, Z. Gitai

The paper introduces M3-Seq, a single-cell RNA-sequencing platform for bacteria, and demonstrates its ability to reveal rare populations and stress response strategies.

bioRxiv · Sep 21, 2022Microbiology

Enhancement of Chikungunya virus genome replication in mammalian cells at a sub-physiological temperature

J. Guo, A. E. Lin, C. Aditya, A. Ploss, M. Harris

This study shows that Chikungunya virus replicates more efficiently in mammalian cells at sub-physiological temperatures due to reduced antiviral responses and enhanced stress granule recruitment.

bioRxiv · Sep 29, 2021 · PreprintMicrobiology

Single-cell profiling of Ebola virus infection in vivo reveals viral and host transcriptional dynamics

D. Kotliar, A. E. Lin, J. Logue, T. K. Hughes, N. M. Khoury, S. S. Raju, M. H. Wadsworth, H. Chen, J. R. Kurtz, B. Dighero-Kemp, Z. B. Bjornson, N. Mukherjee, B. A. Sellers, N. Tran, M. R. Bauer, , R. S. Bennett

This study uses single-cell transcriptomics and protein profiling to analyze EBOV infection in rhesus monkeys, revealing changes in immune cell dynamics and viral/host gene expression.

bioRxiv · Jun 12, 2020 · PreprintMicrobiology

Reporter assays for Ebola virus nucleoprotein oligomerization, virion-like particle budding, and minigenome activity reveal the importance of nucleoprotein amino acid position 111

A. E. Lin, W. E. Diehl, Y. Cai, C. L. Finch, C. Akusobi, R. N. Kirchdoerfer, L. Bollinger, S. F. Schaffner, E. A. Brown, E. O. Saphire, K. G. Andersen, J. H. Kuhn, J. Luban, P. C. Sabeti

The paper develops reporter assays to study Ebola virus nucleoprotein (NP) function and finds that amino acid position 111 affects oligomerization, virion budding, and transcription/replication.

bioRxiv · Dec 10, 2019Microbiology