Author

P. C. Sabeti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Bioengineering· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 6 Organism:human· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

J. E. Lemieux· 3 shared M. R. Bauer· 3 shared A. E. Lin· 2 shared C. M. Rice· 2 shared D.-Y. Chen· 2 shared H. B. Taylor· 2 shared J. G. Abelin· 2 shared J. Luban· 2 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMicrobiology

J. E. Lemieux

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Author profile →

9 papers

Recent·Most cited

North American Powassan virus encompasses diverse in vitro phenotypes.

R. J. McMinn, R. M. Langsjoen, E. J. Normandin, S. D. Stampfer, P. C. Sabeti, A. Piantadosi, G. D. Ebel

This study examines in vitro phenotypic diversity of North American Powassan virus isolates and finds broad differences in replication and cytopathic ability unrelated to geographic or temporal origin or specific genotypes.

bioRxiv · Aug 8, 2023 · PreprintMicrobiology

The HLA-II immunopeptidome of SARS-CoV-2

S. Weingarten-Gabbay, D.-Y. Chen, S. Sarkizova, H. B. Taylor, M. Gentili, L. R. Pearlman, M. R. Bauer, C. M. Rice, K. R. Clauser, N. Hacohen, S. A. Carr, J. G. Abelin, M. Saeed, P. C. Sabeti

The paper identifies SARS-CoV-2 peptides presented by HLA-II complexes, showing their association with CD4+ T cell epitopes and distinct targeting of viral proteins compared to HLA-I.

bioRxiv · May 26, 2023Microbiology

Whole genome sequencing of Borrelia burgdorferi isolates reveals linked clusters of plasmid-borne accessory genome elements associated with virulence.

J. E. Lemieux, W. Huang, N. Hill, T. Cerar, L. Freimark, S. Hernandez, M. Luban, V. Maraspin, P. Bogovic, K. Ogrinc, P. Lapierre, E. Lasek-Nesselquist, N. Singh, R. Iyer, D. Liveris, , K. Strle

This study uses whole genome sequencing of Borrelia burgdorferi isolates to identify plasmid-borne accessory genome elements linked to virulence and dissemination of Lyme disease.

bioRxiv · Feb 26, 2023 · PreprintMicrobiology

SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs

S. Weingarten-Gabbay, S. Klaeger, S. Sarkizova, L. R. Pearlman, D.-Y. Chen, M. R. Bauer, H. B. Taylor, H. L. Conway, C. H. Tomkins-Tinch, Y. Finkel, A. Nachshon, M. Gentili, K. D. Rivera, D. B. Keskin, C. M. Rice, , P. C. Sabeti

The paper identifies HLA-I peptides from SARS-CoV-2 in infected cells, revealing epitopes from both canonical and out-of-frame ORFs, which could inform vaccine development.

bioRxiv · Oct 2, 2020 · PreprintImmunology

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

L. Yurkovetskiy, X. Wang, K. E. Pascal, C. Tompkins-Tinch, T. Nyalile, Y. Wang, A. Baum, W. E. Diehl, A. Dauphin, C. Carbone, K. Veinotte, S. B. Egri, S. F. Schaffner, J. E. Lemieux, J. Munro, , J. Luban

This study shows the D614G SARS-CoV-2 spike protein variant is more infectious but has reduced ACE2 affinity and altered trimer conformation, affecting viral entry and antibody neutralization.

bioRxiv · Jul 4, 2020Microbiology

Single-cell profiling of Ebola virus infection in vivo reveals viral and host transcriptional dynamics

D. Kotliar, A. E. Lin, J. Logue, T. K. Hughes, N. M. Khoury, S. S. Raju, M. H. Wadsworth, H. Chen, J. R. Kurtz, B. Dighero-Kemp, Z. B. Bjornson, N. Mukherjee, B. A. Sellers, N. Tran, M. R. Bauer, , R. S. Bennett

This study uses single-cell transcriptomics and protein profiling to analyze EBOV infection in rhesus monkeys, revealing changes in immune cell dynamics and viral/host gene expression.

bioRxiv · Jun 12, 2020 · PreprintMicrobiology

Integrated sample inactivation, amplification, and Cas13-based detection of SARS-CoV-2

J. Arizti-Sanz, C. A. Freije, A. C. Stanton, C. K. Boehm, B. A. Petros, S. Siddiqui, B. M. Shaw, G. Adams, T.-S. F. Kosoko-Thoroddsen, M. E. Kemball, R. Gross, L. Wronka, K. Caviness, L. E. Hensley, N. H. Bergman, , C. Myhrvold

This paper develops SHINE, a diagnostic tool for SARS-CoV-2 detection with 90% sensitivity and 100% specificity, reducing contamination risk and enabling use outside clinical settings.

bioRxiv · May 28, 2020 · PreprintBioengineering

Reporter assays for Ebola virus nucleoprotein oligomerization, virion-like particle budding, and minigenome activity reveal the importance of nucleoprotein amino acid position 111

A. E. Lin, W. E. Diehl, Y. Cai, C. L. Finch, C. Akusobi, R. N. Kirchdoerfer, L. Bollinger, S. F. Schaffner, E. A. Brown, E. O. Saphire, K. G. Andersen, J. H. Kuhn, J. Luban, P. C. Sabeti

The paper develops reporter assays to study Ebola virus nucleoprotein (NP) function and finds that amino acid position 111 affects oligomerization, virion budding, and transcription/replication.

bioRxiv · Dec 10, 2019Microbiology

Comparative evidence for the independent evolution of hair and sweat gland traits in primates

Y. G. Kamberov, S. M. Guhan, A. DeMarchis, J. Jiang, S. S. Wright, B. A. Morgan, P. C. Sabeti, C. J. Tabin, D. E. Lieberman

The paper compares hair follicle and eccrine sweat gland density across macaques, chimpanzees, and humans, finding humans have lower hair density and higher sweat gland density than other primates.

bioRxiv · Sep 29, 2018Evolutionary Biology