M. Otsuka

Single-cell and spatial atlas of steatotic liver-related hepatocellular carcinoma

This study characterizes the tumor microenvironment of steatotic liver-related hepatocellular carcinoma using single-cell and spatial transcriptomic analyses, identifying immunosuppressive features and Treg-CAF interactions linked to immunotherapy resistance.

A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24

This paper identifies a heterocyclic compound, HT-7, that inhibits HIV-1 release by increasing cell surface BST2 expression with minimal cellular toxicity.

Rapid and Efficient Ambient Temperature X-ray Crystal Structure Determination at Turkish Light Source

The paper introduces a plate-reader module for rapid ambient temperature X-ray crystallography at a home source and reports the first lysozyme structure determined at Turkish DeLight.

Cryogenic X-ray crystallographic studies of biomacromolecules at Turkish Light Source: Turkish DeLight

The paper describes the setup and application of a new X-ray crystallography facility in Turkey for structural analysis of biomacromolecules using lysozyme as a model.

Structural insight into host plasma membrane association and assembly of HIV-1 Matrix protein

This study presents crystal structures of HIV-1 MA domain bound to IP6, revealing its binding mode and interaction with PIP2, providing insights into virion assembly.

Serial femtosecond X-ray diffraction of HIV-1 Gag MA-IP6 microcrystals at ambient temperature

This study uses serial femtosecond X-ray crystallography to analyze HIV-1 Gag MA-IP6 microcrystals at ambient temperature, achieving high-resolution diffraction data.

Cross-sectional and longitudinal research approaches: running pace and step characteristics of elite athletes in the 400-m hurdles

This study compares cross-sectional and longitudinal analyses of running pace and step characteristics in elite 400-m hurdlers, finding discrepancies between performance metrics and training implications.