Author

W. Zhen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biophysics· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:dimensionality reduction· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

G. J. Berry· 2 shared Y. Wang· 2 shared B. Huang· 1 shared B. Li· 1 shared B. Zhang· 1 shared C. Ma· 1 shared C. Qin· 1 shared C. W. Ke· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersPathology

G. J. Berry

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A common mechanism of temperature-sensing in thermoTRP channels

L. Xu, X. Liang, W. Zhen, Z. Xue, F. Zhang, X. Yi, X. Chen, L. Hu, B. Li, B. Zhang, Y. Wang, Z. Deng, W. Yang, H. Wen, T. Guo, , Y. Fan

This study identifies a common mechanism for temperature sensing in TRPM8 and TRPV1 thermoTRP channels through water-protein interaction changes.

bioRxiv · May 23, 2022 · PreprintBiophysics

Structure and computation-guided design of a mutation-integrated trimeric RBD candidate vaccine with broad neutralization against SARS-CoV-2

Y. Liang, J. Zhang, R. Y. Yuan, M. Y. Wang, P. He, J. G. Su, Z. B. Han, Y. Q. Jin, J. W. Hou, H. Zhang, X. F. Zhang, S. Shao, Y. N. Hou, Z. M. Liu, L. F. Du, , Q. M. Li

This paper designs a trimeric RBD vaccine candidate with mutations from multiple SARS-CoV-2 strains, showing broad neutralization against variants including Beta and Kappa.

bioRxiv · Jun 18, 2021 · PreprintImmunology

Design of a Novel Multiplex Real Time RT-PCR Assay for SARS-CoV-2 Detection

W. Zhen, G. J. Berry

This paper designs and evaluates a multiplex RT-PCR assay for SARS-CoV-2 detection, showing comparable performance to the modified CDC assay with higher efficiency and lower reagent use.

bioRxiv · Jun 4, 2020 · PreprintPathology

Analytical and Clinical Comparison of Three Nucleic Acid Amplification Tests for SARS-CoV-2 Detection

E. Smith, W. Zhen, R. Manji, D. Schron, S. Duong, G. J. Berry

This study compares three SARS-CoV-2 nucleic acid amplification tests, finding similar limit of detection but differences in absolute quantification and clinical performance.

bioRxiv · May 14, 2020Microbiology

The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice

L. Bao, W. Deng, B. Huang, H. Gao, J. Liu, L. Ren, Q. Wei, P. Yu, Y. Xu, F. Qi, Y. Qu, F. Li, Q. Lv, W. Wang, J. Xue, , C. Qin

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

bioRxiv · Feb 7, 2020Microbiology