Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine
J. Cao, M. Li, K. Liu, X. Shi, N. Sui, Y. Yao, X. Wang, S. Tan, Q. Zhao, L. Wang, X. Chai, L. Zhang, C. Liu, X. Li, Z. Chang, , T. Zhao
This paper shows that oxidative phosphorylation (OXPHOS) generates most ATP in mouse ESCs and is essential for pluripotency by coupling with the hexosamine biosynthesis pathway to produce UDP-GlcNAc.
bioRxiv · Jul 6, 2021Cell Biology