Z. Chang

Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine

This paper shows that oxidative phosphorylation (OXPHOS) generates most ATP in mouse ESCs and is essential for pluripotency by coupling with the hexosamine biosynthesis pathway to produce UDP-GlcNAc.

Cytokinin oxidase/dehydrogenase family genes exhibit functional divergence and overlap in rice growth and development, especially in control of tillering

This study investigates the functional roles of OsCKX genes in rice by generating mutants, revealing functional overlap and subfunctionalization, and identifying gene expression changes related to auxin and cytokinin pathways.

Momilactone B inhibits Arabidopsis growth and development via disruption of ABA and auxin signaling

Momilactone B inhibits Arabidopsis growth and development by disrupting ABA and auxin signaling, highlighting the role of phytohormones in allelopathic responses.

SingleChannelNet: A Model for Automatic Sleep Stage Classification with Raw Single-Channel EEG

SingleChannelNet is a deep learning model that automatically classifies sleep stages from raw single-channel EEG data, achieving high accuracy without hand-crafted features or multi-modality data.

Multi-omic analysis of subtype evolution and heterogeneity in high-grade serous ovarian carcinoma

This paper investigates the evolution and heterogeneity of high-grade serous ovarian carcinoma using multi-omic analysis, finding that subtypes emerge later in tumor development and are not discrete but rather part of a continuous spectrum.

Lesions of canine prostate underwent laser ablation, radiofrequency ablation, and microwave ablation: Lesions shapes and clinical significances

This study compares the shapes and sizes of prostate lesions in dogs treated with laser, radiofrequency, and microwave ablation, finding significant differences in lesion morphology and volume.

High-throughput living-cell protein crosslinking analysis uncovers the physiological relevance of forming the \"inserted\" state of the ATP synthase ϵ-subunit

The paper uses living-cell protein crosslinking to show the ε-subunit of ATP synthase exists in an equilibrium of inserted and non-inserted states, with inserted state enhancing ATP synthesis under stress.

Drug-resistant epimutants exhibit organ-specific stability and induction during murine infections caused by the human fungal pathogen Mucor circinelloides

This study shows that epimutation in Mucor circinelloides can be induced and reverted in a murine infection model, with higher rates observed in brain infections compared to other organs.

Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides

The paper identifies RNAi-dependent epimutation as a mechanism for broad antifungal resistance in Mucor circinelloides, showing it can silence multiple genes involved in antifungal metabolism.

Regrowth-delay Body as a Bacterial Subcellular Structure marking multidrug tolerant Persisters

The paper identifies a new subcellular structure, the regrowth-delay body, in bacterial persisters and links its presence to multidrug tolerance and regrowth delay.

Absence of GdX/UBL4A protects against inflammatory bowel diseases by regulating NF-κB signaling in DCs and macrophages