Chenchun Weng

Multimodal allostery in a single-domain protein

This study maps allosteric communication in KRAS, revealing three distinct modes of allostery and highlighting the complexity of regulatory networks in single-domain proteins.

Spatially clustered piRNA genes promote the transcription of piRNAs via condensate formation of the H3K27me3 reader UAD-2

The paper shows that spatial clustering of piRNA genes in nematodes enhances transcription through phase separation involving UAD-2 and the SUMO regulatory factors GEI-17 and TOFU-3.

CDE-1 suppresses the production of risiRNA by coupling polyuridylation and degradation of 26S rRNA

The paper identifies CDE-1 as a factor that suppresses risiRNA production by polyuridylating and degrading 26S rRNA in C. elegans.

Differential phase partition of a PICS complex is required for piRNA processing and chromosome segregation in C. elegans

The paper identifies a PICS complex involved in piRNA processing and chromosome segregation in C. elegans, with distinct localization and function in different cellular contexts.

The USTC complex co-opts an ancient machinery to drive piRNA transcription in C. elegans

The paper identifies the USTC complex as essential for piRNA transcription in C. elegans, revealing its role in genome defense through specific binding to piRNA clusters.

A cytoplasmic Argonaute protein promotes the inheritance of RNAi

The paper identifies WAGO-4, a cytoplasmic Argonaute protein, as essential for the inheritance of RNAi in C. elegans, showing its role in translocating to the germline and binding 22G-RNAs.