Xiangyang Chen

TurboID-based proximity labeling identifies novel germline proteins that maintain E granule integrity and small RNA homeostasis in C. elegans

The paper identifies two novel proteins, EGC-2 and EGC-3, that are essential for E granule assembly and small RNA homeostasis in C. elegans using TurboID-based proximity labeling and RNAi screening.

rRNA intermediates dictate nucleolar architecture in C. elegans

This study shows that rRNA intermediates influence nucleolar structure in C. elegans by altering protein distribution and causing architectural changes.

Compartmentalized localization of perinuclear proteins within germ granules in C. elegans

The paper identifies subcompartments within C. elegans germ granules and maps perinuclear proteins to specific regions, revealing a novel D granule and the role of MIP-1/EDDG-1 in germ granule architecture.

Peri-centrosomal localization of small interfering RNAs in C. elegans

The paper identifies peri-centrosomal localization of siRNAs in C. elegans using NRDE-3 as a reporter, showing dependence on 22G siRNAs and centrosomal components.

Systematic characterization of chromodomain proteins revealsan H3K9me1/2 reader regulating aging in C. elegans

The paper systematically characterizes chromodomain proteins in C. elegans, identifying CEC-5 as an H3K9me1/2 reader that regulates aging through interactions with MET-2.

A ZTF-7/RPS-2 complex mediates the cold-warm response in C. elegans

The paper identifies a ZTF-7/RPS-2 complex involved in C. elegans' response to cold-warm temperature changes by regulating RNA exosome localization.

Co-surveillance of ribosomal RNA by the exosome complex and nucleolar RNAi in C. elegans

The paper identifies factors involved in risiRNA generation in C. elegans and shows their role in rRNA surveillance through exosome and nucleolar RNAi mechanisms.

CDE-1 suppresses the production of risiRNA by coupling polyuridylation and degradation of 26S rRNA

The paper identifies CDE-1 as a factor that suppresses risiRNA production by polyuridylating and degrading 26S rRNA in C. elegans.

A cytoplasmic Argonaute protein promotes the inheritance of RNAi

The paper identifies WAGO-4, a cytoplasmic Argonaute protein, as essential for the inheritance of RNAi in C. elegans, showing its role in translocating to the germline and binding 22G-RNAs.