Excessive Ca2+-dependent ER-mitochondrial contact stabilization by EFHD1 drives liver injury
David Eberhardt, Emma C. Rekate, Yasmin B Masini, Hannah E. Duron, David M. Mollinedo, Adrian M Velarde, DEVORAH STUCKI, Tara R. Price, Sandra H. J. Lee, Enrique Balderas, Neeraj K Rai, Ashley R. Bratt, Anthony M. Balynas, Chris Stubben, Ryan D. Bia, , Dipayan Chaudhuri
This study identifies EFHD1 as a Ca2+-dependent stabilizer of ER-mitochondrial contacts that drives liver injury in MASH by promoting mitochondrial fragmentation and antiviral stress responses.
bioRxiv · Feb 16, 2026 · PreprintCell Biology