R. Chari

Targeting the sphingolipid rheostat in IDH1mut glioma alters cholesterol homeostasis and triggers apoptosis via membrane degradation

This study shows that altering sphingosine levels in IDH1mut glioma cells disrupts cholesterol homeostasis, leading to apoptosis through effects on cholesterol synthesis, uptake, and efflux.

EWSR1's visual modalities are defined by its association with nucleic acids and RNA polymerase II

This study identifies two visual modalities of EWSR1 in the nucleoplasm, both associated with nascent RNA, and shows EWSR1 foci localize to euchromatin and phosphorylated RNA polymerase II.

Identification of KIFC1 as a putative vulnerability in lung cancers with centrosome amplification

This study identifies KIFC1 as a therapeutic vulnerability in lung cancers with centrosome amplification by showing its role in mitigating mitotic stress.

Comprehensive mapping of cell fates in microsatellite unstable cancer cells support dual targeting of WRN and ATR

This study maps the cellular response to WRN loss in MSI-H cancers, showing DNA damage accumulation and cell death, and suggests dual targeting of WRN and ATR as a therapeutic strategy.

Mitochondrial Matrix Protease ClpP Agonists inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis

This study shows that ClpP agonists inhibit breast cancer stem cell function by disrupting mitochondrial homeostasis and multiple metabolic pathways.

Protonation-Dependent Sequencing of 5-Formylcytidine in RNA

This paper develops a protonation-dependent sequencing method to detect 5-formylcytidine and 5-carboxycytidine in RNA, demonstrating its application in human tRNA and a 5fC-deficiency model.

Disc Large Homolog 1 is critical for early microcluster formation and activation in human T cells

This study shows DLG1 is essential for early TCR-microcluster formation and T cell activation by bridging TCR-zeta and ZAP70 while blocking SHP1 binding.