T. Fukagawa

Nuclear membrane protein Bqt4 maintains nuclear envelope integrity by recruiting phosphatidic acid

This study identifies Bqt4 as an inner nuclear membrane protein that recruits phosphatidic acid to maintain nuclear envelope integrity in fission yeast.

A ubiquitin-proteasome pathway degrades the inner nuclear membrane protein Bqt4 to maintain nuclear membrane homeostasis

The paper identifies the ubiquitin-proteasome pathway as a mechanism for degrading the inner nuclear membrane protein Bqt4 to maintain nuclear membrane homeostasis.

The centromere/kinetochore is assembled through CENP-C oligomerization

This study shows that CENP-C oligomerization is essential for centromere function by organizing centromeric chromatin and maintaining kinetochore assembly in vertebrates.

Condensin reorganizes centromeric chromatin during mitotic entry into a bipartite structure stabilized by cohesin

This study shows vertebrate centromeres form a bipartite structure during mitosis, stabilized by condensin and linked by cohesin, which prevents merotelic attachments and chromosomal instability.

The cryo-EM structure of the CENP-A nucleosome in complex with ggKNL2

The paper presents the cryo-EM structure of the chicken CENP-A nucleosome complexed with ggKNL2, revealing how ggKNL2 recognizes CENP-A and facilitates its deposition.

A super sensitive auxin-inducible degron system with an engineered auxin-TIR1 pair

The paper develops an improved auxin-inducible degron system with an engineered auxin-TIR1 pair that reduces auxin concentration requirements and enables efficient protein depletion in human and mouse cells.

Identification of bridgin, an unconventional linker, connects the outer kinetochore to centromeric chromatin

The paper identifies bridgin, a new linker protein in fungi, that connects the outer kinetochore to centromeric chromatin, differing from known linker proteins.

Live-cell imaging of marked chromosome regions reveals dynamics of mitotic chromosome resolution and compaction

The paper uses live-cell imaging to study mitotic chromosome resolution and compaction dynamics, revealing their timing and regulation.