Author

Y. Ichimura

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. Komatsu· 3 shared M. Koike· 2 shared N. N. Noda· 2 shared S. Kageyama· 2 shared S. Komatsu-Hirota· 2 shared S. Waguri· 2 shared Y.-S. Sou· 2 shared A. H. El-Gowily· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCell Biology

M. Komatsu

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Author profile →

3 papers

Recent·Most cited

Loss of SPNS1, a lysosomal transporter, in the nervous system causes dysmyelination and white matter dysplasia

Y. Ichimura, Y. Sugiura, Y. Katsuragi, Y.-S. Sou, T. Uemura, N. Tamura, S. Komatsu-Hirota, T. Ueno, M. Koike, S. Waguri, M. Komatsu

This study shows that loss of SPNS1 in the nervous system causes dysmyelination and white matter dysplasia in mice, suggesting a role for SPNS1 mutations in human congenital white matter disorders.

bioRxiv · May 29, 2024 · PreprintCell Biology

Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response

M. Komatsu, R. Ikeda, D. Noshiro, H. Morishita, S. Takada, S. Kageyama, Y. Fujioka, T. Funakoshi, S. Komatsu-Hirota, R. Arai, E. Ryzhii, M. Abe, T. Koga, M. Nakao, K. Sakimura, , N. N. Noda

This study identifies ULK1 as the kinase responsible for phosphorylating p62, which activates NRF2 in a redox-independent manner through retention of KEAP1 in p62 bodies.

bioRxiv · Dec 21, 2022Cell Biology

Droplets of amyotrophic lateral sclerosis-associated p62/SQSTM1 mutants show slower inner fluidity

F. M. Omar, Y. Ichimura, S. Kageyama, A. H. El-Gowily, Y.-s. Sou, M. Koike, N. N. Noda, M. Komatsu

This study investigates how ALS/FTD-related p62 mutations affect liquid droplet properties, finding that some mutants show reduced Nrf2 activation and delayed turnover, while all exhibit slower inner fluidity.

bioRxiv · Jun 7, 2021Cell Biology