Y. Sakamaki

Discovery of Novel Replication Proteins for Large Plasmids in Cyanobacteria and Their Potential Applications in Genetic Engineering

This study identifies two novel replication proteins, CyRepX1 and CyRepX2, from a cyanobacterial plasmid and demonstrates their compatibility with existing replication systems, suggesting potential applications in genetic engineering.

Intradermal Administration of Rescue Dose of Antiemetics in Chemotherapy-induced Nausea and Vomiting

The paper compares the pharmacokinetics of subcutaneous and intradermal antiemetic administration in rats to evaluate their effectiveness for rapid, self-administered rescue therapy for chemotherapy-induced nausea and vomiting.

NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and endosomal microferritinophagy

This study identifies NCOA4 as a driver of ferritin phase separation, enabling macroferritinophagy and endosomal microferritinophagy through multivalent interactions.

TBC1D18, a novel Rab5-GAP, coordinates endosome maturation together with Mon1

This study identifies TBC1D18 as a novel Rab5-GAP that works with Mon1 to regulate endosome maturation by inactivating Rab5.

An Autophagy-Dependent Tubular Lysosomal Network Synchronizes Degradative Activity Required for Muscle Remodeling

The paper identifies a tubular autolysosomal network in Drosophila muscle remodeling that synchronizes degradative activity, marked by Syntaxin 17 and dependent on autophagy.

ALIX and ceramide differentially control polarized exosome release from epithelial cells

The paper identifies two distinct mechanisms for polarized exosome release from epithelial cells: ALIX-Syntenin1-Syndecan1 for apical exosomes and ceramide production for basolateral exosomes.