Author

Y.-W. Cheng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:virus· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

H.-Y. Wang· 2 shared P.-J. Chen· 2 shared S.-H. Yeh· 2 shared S.-Y. Chang· 2 shared T.-L. Chao· 2 shared A. P. Hinck· 1 shared A. R. Anzell· 1 shared B. L. Roman· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersEvolutionary Biology

H.-Y. Wang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Shear stress and very low levels of ligand synergize toactivate ALK1 signaling in endothelial cells

Y.-W. Cheng, A. R. Anzell, T. A. Schwartze, C. S. Hinck, A. P. Hinck, B. L. Roman, L. Davidson

The paper investigates how shear stress and low ALK1 ligand levels synergize to activate ALK1 signaling in endothelial cells, revealing kinase activity and endocytosis as critical factors.

bioRxiv · Nov 1, 2023 · PreprintCell Biology

Intra-Host Mutation Rate of Acute SARS-CoV-2 Infection During the Initial Pandemic Wave

K. El Haddad, T. M. Adhikari, T. Zheng, Y.-W. Cheng, X. Leng, X. Zhang, D. Rhoads, J. Ko, S. Worley, J. Li, B. Rubin, F. Esper

This study quantifies the intra-host mutation rate of SARS-CoV-2 during acute infection and finds higher mutation rates in viruses with NSP-14 mutations and in immunocompromised patients.

bioRxiv · Mar 24, 2023Evolutionary Biology

Antagonistic pleiotropy plays an important role in governing the evolution and genetic diversity of SARS-CoV-2

D.-C. Lee, J.-H. Tai, H.-F. Lin, T.-L. Chao, Y. Ruan, Y.-W. Cheng, Y.-C. Chou, Y.-Y. Lin, S.-Y. Chang, P.-J. Chen, S.-H. Yeh, H.-Y. Wang

The paper examines how antagonistic pleiotropy influences SARS-CoV-2 evolution and genetic diversity by analyzing genomic mutations and their functional impacts.

bioRxiv · Feb 10, 2023Evolutionary Biology

D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Viral Transmission via Enhanced Furin-mediated Spike Cleavage

Y.-W. Cheng, T.-L. Chao, C.-L. Li, S.-H. Wang, H.-C. Kao, Y.-M. Tsai, H.-Y. Wang, C.-L. Hsieh, P.-J. Chen, S.-Y. Chang, S.-H. Yeh

This study shows the D614G substitution in SARS-CoV-2 spike protein increases viral transmission by enhancing furin-mediated cleavage, leading to more syncytium formation and higher virus titers.

bioRxiv · Jan 27, 2021Microbiology