Author

S.-H. Wang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Research Focus:protein folding & dynamics· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1

Frequent Co-Authors

N. L. Fawzi· 4 shared J. Mittal· 2 shared T. Zheng· 2 shared A. A. Hyman· 1 shared A. Allue-Guardia· 1 shared A. C. Murthy· 1 shared A. Garcia-Vilanova· 1 shared A. Honigmann· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersBiochemistry

N. L. Fawzi

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Impact of the elderly lung mucosa on Mycobacterium tuberculosis metabolic adaptation during infection of alveolar epithelial cells

A. M. Olmo-Fontanez, A. Allue-Guardia, A. Garcia-Vilanova, J. Glenn, S.-H. Wang, R. E. Merritt, L. S. Schlesinger, J. Turner, Y. Wang, J. B. Torrelles

This study shows that elderly lung mucosa alters Mycobacterium tuberculosis gene expression, enhancing its metabolic adaptation and survival in alveolar epithelial cells.

bioRxiv · May 6, 2024 · PreprintMicrobiology

Expanding the molecular grammar of polar residues and arginine in FUS prion-like domain phase separation and aggregation

N. Wake, S.-L. Weng, T. Zheng, S.-H. Wang, V. Kirilenko, J. Mittal, N. L. Fawzi

The paper expands the molecular grammar of polar residues and arginine in FUS prion-like domain phase separation and aggregation by showing additional residues contribute to these processes.

bioRxiv · Feb 15, 2024Biochemistry

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates

X. Yan, D. Kuster, P. Mohanty, J. Nijssen, K. Pombo-Garcia, A. Rizuan, T. M. Franzmann, A. Sergeeva, P. M. dos Passos, L. George, S.-H. Wang, J. Shenoy, H. L. Danielson, A. Honigmann, Y. M. Ayala, , A. A. Hyman

This study shows that TDP-43 aggregation in stress granules requires up-concentration and oxidative stress, leading to intra-condensate demixing and pathological aggregates.

bioRxiv · Jan 23, 2024Cell Biology

Intrinsically disordered regions and RNA binding domains contribute to protein enrichment in biomolecular condensates in Xenopus oocytes

L. C. O'Connell, V. Johnson, A. K. Hutton, J. P. Otis, A. C. Murthy, M. C. Liang, S.-H. Wang, N. L. Fawzi, K. L. Mowry

bioRxiv · Nov 10, 2023 · PreprintCell Biology

Structure and position-specific interactions of prion-like domains in transcription factor Efg1 phase separation

T. Zheng, S.-H. Wang, N. L. Fawzi

This study investigates the structural and interaction details of Efg1's prion-like domains during phase separation in Candida albicans, revealing helical structures and residue-specific interactions critical for the transcriptional switch between white and opaque cell states.

bioRxiv · Nov 9, 2023Biochemistry

Effect of flavonoids hydroxygenkwanin on vascular smooth muscle cell proliferation, migration, and neointimal formation

C.-C. Chen, M.-S. Lin, P.-Y. Chen, Y.-L. Leu, S.-H. Wang

This study evaluates hydroxygenkwanin's effect on vascular smooth muscle cell proliferation, migration, and neointimal formation, finding it inhibits these processes via the PDK1/AKT/mTOR pathway and promotes endothelial progenitor cell chemotaxis.

bioRxiv · Dec 20, 2022 · PreprintCell Biology

D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Viral Transmission via Enhanced Furin-mediated Spike Cleavage

Y.-W. Cheng, T.-L. Chao, C.-L. Li, S.-H. Wang, H.-C. Kao, Y.-M. Tsai, H.-Y. Wang, C.-L. Hsieh, P.-J. Chen, S.-Y. Chang, S.-H. Yeh

This study shows the D614G substitution in SARS-CoV-2 spike protein increases viral transmission by enhancing furin-mediated cleavage, leading to more syncytium formation and higher virus titers.

bioRxiv · Jan 27, 2021Microbiology