Author

T.-L. Chao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:virus· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

S.-Y. Chang· 5 shared Y.-M. Tsai· 4 shared H.-C. Kao· 3 shared H.-Y. Wang· 2 shared P.-J. Chen· 2 shared S.-H. Yeh· 2 shared Y.-C. Chou· 2 shared Y.-W. Cheng· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersMicrobiology

S.-Y. Chang

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A robust platform for BaEVRless-lentiviral synthesis and primary natural killer cell transduction

Y.-J. Lan, Q. V. Nguyen, T.-L. Chao, K.-L. Yeh, S. Lin

This paper develops a robust platform for producing BaEVRless-lentiviral vectors for transducing primary natural killer cells by optimizing production in ASCT2-KO HEK293T cells.

bioRxiv · Apr 3, 2024 · PreprintImmunology

Antagonistic pleiotropy plays an important role in governing the evolution and genetic diversity of SARS-CoV-2

D.-C. Lee, J.-H. Tai, H.-F. Lin, T.-L. Chao, Y. Ruan, Y.-W. Cheng, Y.-C. Chou, Y.-Y. Lin, S.-Y. Chang, P.-J. Chen, S.-H. Yeh, H.-Y. Wang

The paper examines how antagonistic pleiotropy influences SARS-CoV-2 evolution and genetic diversity by analyzing genomic mutations and their functional impacts.

bioRxiv · Feb 10, 2023Evolutionary Biology

Equilibrative Nucleoside Transporter 3 is an IFN-stimulated Gene that Facilitates Viral Genome Release

Y.-T. Hsieh, T.-L. Tsai, C.-C. Tu, S.-Y. Huang, J.-W. Heng, P.-Y. Tsai, T.-L. Chao, Y.-M. Tsai, P.-C. Chang, C.-K. Lee, G.-Y. Yu, S.-Y. Chang, I. Dzhagalov, C.-L. Hsu

This study identifies ENT3 as an IFN-stimulated gene that supports viral genome release, showing its role in viral entry and replication.

bioRxiv · Apr 27, 2022 · PreprintImmunology

Impact of glycosylation on a broad-spectrum vaccine against SARS-CoV-2

H.-Y. Huang, H.-Y. Liao, X. Chen, S.-W. Wang, C.-W. Cheng, M. Shahed-Al-Mahmud, T.-H. Chen, J. M. Lo, Y.-M. Liu, Y.-M. Wu, H.-H. Ma, Y.-H. Chang, H.-Y. Tsai, Y.-C. Chou, Y.-P. Hsueh, , C.-H. Wong

This study shows that trimming N-glycans from the SARS-CoV-2 spike protein enhances immune responses and protection against variants in hACE2 mice.

bioRxiv · May 25, 2021 · PreprintMicrobiology

D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Viral Transmission via Enhanced Furin-mediated Spike Cleavage

Y.-W. Cheng, T.-L. Chao, C.-L. Li, S.-H. Wang, H.-C. Kao, Y.-M. Tsai, H.-Y. Wang, C.-L. Hsieh, P.-J. Chen, S.-Y. Chang, S.-H. Yeh

This study shows the D614G substitution in SARS-CoV-2 spike protein increases viral transmission by enhancing furin-mediated cleavage, leading to more syncytium formation and higher virus titers.

bioRxiv · Jan 27, 2021Microbiology

Distinct Inductions of and Responses to Type I and Type III Interferons PromoteInfections in Two SARS-CoV-2 Isolates

F. Hsin, T.-L. Chao, Y.-R. Chan, H.-C. Kao, W.-D. Liu, J.-T. Wang, Y.-H. Pang, C.-H. Lin, Y.-M. Tsai, J.-Y. Lin, S.-Y. Chang, H. M. Liu

This study compares two SARS-CoV-2 isolates and finds they induce weak antiviral responses and are less neutralized by antibodies.

bioRxiv · Apr 30, 2020 · PreprintMicrobiology