Author

Yangyi Zhang

Chinese University of Hong Kong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Molecular Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew J. DeansiD· 1 shared Chih-Hung HsuiD· 1 shared Clare L. ScottiD· 1 shared Dian Wang· 1 shared Elaine SanijiD· 1 shared Hao CheniD· 1 shared Hsi‐Yuan HuangiD· 1 shared Hsien-Da HuangiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperMolecular Biology

Andrew J. DeansORCID

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Author profile →

3 papers

Recent·Most cited

MIRCID: Inferred Hub-miRNAs Drive Cross-Task Improvements in Drug Mechanistic Modeling

Xin Cao, Yigang Chen, Jiatong Xu, Ziyue Zhang, Xiang Cheng, Shenyu Wang, Yangyi Zhang, Xiaoxuan Cai, Shidong Cui, Zihao Zhu, Xiang Ji, Hsi‐Yuan Huang, Yang-Chi-Dung Lin, Hsien-Da Huang

MIRCID improves drug mechanism modeling by integrating inferred hub miRNAs with gene expression and TF activity, showing better performance than TF activity alone.

bioRxiv · Sep 23, 2026 · PreprintBioinformatics

EOLA1, a novel mitochondria-localized protein critical for heart functions via regulating mitochondrial translation

Xiaoyan Shi, Yangyi Zhang, Nanbo Liu, Ruiqi Wang, Nan Zhang, Yanlan Cao, Dian Wang, Yuxuan Jin, Qingren Meng, Simin Fan, Jia Yao, Chih-Hung Hsu, Shuoji Zhu, Ping Zhu, Yang Shi, Hao Chen

This study identifies EOLA1 as a mitochondrial protein critical for translation and heart function through interactions with 12S mt-rRNA and TUFM.

bioRxiv · Jan 12, 2026 · PreprintMolecular Biology

Local nucleolar surveillance mechanisms maintain rDNA stability

Ruofei Liu, Jiachen Xuan, Junqi Pan, Shalini Sundramurthi Chelliah, Rhynelle Dmello, Karla J. Cowley, Shannon Mendez, Yangyi Zhang, Kezia Gitareja, Matthew Wakefield, Andrew J. Deans, Clare L. Scott, Keefe T. Chan, Kaylene J. Simpson, Jian Kang, Elaine Sanij

This study identifies localized nucleolar surveillance mechanisms that respond to rDNA damage by activating the nucleolar DNA damage response (nDDR) through R-loop formation and RAD54L protection.

bioRxiv · Jan 20, 2025 · PreprintMolecular Biology