Integrin-independent Tie2 activation using de novo designed proteins
Clara McCurdy, Yan Ting Zhao, Saurav Kumar, Brian Coventry, Anne Pink, Yaoyao Fu, Phillip Bohn, Siyu Zhu, Inna Goreshnik, Xinru Wang, Garrett Ruth, Rashmi Ravichandran, Julie Mathieu, Jonathan A. Cooper, DEBORAH HEYDENBURG FULLER, , Hannele Ruohola‐Baker
This paper designs a de novo Tie2 binder that activates the Angiopoietin-Tie2 pathway without integrin engagement, showing improved therapeutic potential in a mouse model of ARDS.
bioRxiv · May 2, 2026 · PreprintBiochemistry