Fatty acid scavenging enables cancer escape from KRAS inhibition
Zihang Yuan, Bo Lin, Chunlan Wang, Yingying Miao, Da Zhang, Ziru Meng, Gangqi Wang, Andrew M. Lowy, Michael Karin, F Y Yang, Beicheng Sun, Hua Su
The paper identifies a metabolic adaptation in KRAS-inhibited cancer cells that enables resistance through fatty acid scavenging via ADGRB1-PI3Kγ signaling, and shows targeting this pathway restores sensitivity to KRAS inhibitors.
bioRxiv · Apr 3, 2026 · PreprintCancer Biology