Efficient Generation of Functional TCRαβ+ Cytotoxic T Cells from hiPSCs via Small-Molecule Modulation
Caroline Kubaczka, Netra K. Kambli, Roland Windisch, Kelly Yu, Yunliang Zhao, Sharon Wu, Katie Frenis, Morgan T. Walcheck, Marcelo Falchetti, Mohamad Ali Toufic Najia, Zachary C. LeBlanc, Trista E. North, R. Grant Rowe, George Q. Daley, Thorsten M. Schlaeger
This paper identifies small-molecule modulators that enhance the generation of functional cytotoxic T cells from hiPSCs, increasing CTL production up to 2000-fold.
bioRxiv · Apr 1, 2026 · PreprintCell Biology