Qinheng Zheng

Single-sequence deep learning delivers crystal-quality models of covalent K-Ras G12 hotspot complexes

The paper demonstrates that Chai-1, a deep learning tool, can accurately predict covalent K-Ras(G12C) complexes using single sequences without multiple sequence alignments.

Molecular logic of pheromone recognition enables rational design of insect behavior modulators

This paper decodes the structural logic of pheromone recognition in silkmoths to design small molecules that disrupt insect mating behavior.

Reshaping the tumor microenvironment by degrading glycoimmune checkpoints Siglec-7 and -9

This study develops a degrader for Siglec-7 and -9 to reshape the tumor microenvironment and enhance T cell anti-tumor immunity in murine models.