Author

Valentina Davì

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:electrophysiology· 1 Approach:statistical model· 1

Frequent Co-Authors

Edward AvezoviD· 3 shared Tasuku KonnoiD· 2 shared Alfonso De SimoneiD· 1 shared Amberley D. StephensiD· 1 shared Ana Fernández‐VillegasiD· 1 shared Annelies QuaegebeuriD· 1 shared Arkoprovo PauliD· 1 shared Bismoy Mazumder· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersNeuroscience

Edward AvezovORCID

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Author profile →

3 papers

Recent·Most cited

Tau aggregate replication occurs at the pre-synapse of cultured human neurons and increases with application of TNFa

Shekhar Kedia, Emre Fertan, Arkoprovo Paul, Valentina Davì, George Nolan, Koby Baranes, Yunzhao Wu, Jae Eun Kim, Annelies Quaegebeur, Mark Kotter, Edward Avezov, Georg Meisl, David Klenerman

The paper shows TNFα promotes tau aggregation at pre-synapses in human neurons, forming non-fibrillar aggregates that replicate rapidly.

bioRxiv · Jun 3, 2026 · PreprintNeuroscience

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates

Valentina Davì, Pierre Parutto, Cécile C. Crapart, Yuyi Zhang, Tasuku Konno, Joseph E. Chambers, John P Franklin, Daniel C. Maddison, Mosab Ali Awadelkareem, Michael J. Devine, Elena F. Koslover, Edward Avezov

The paper shows that ER morphology affects neuronal bursting by controlling Ca2+ refill rates, linking ER structure to neuronal activity and neurodegeneration.

bioRxiv · Oct 6, 2025 · PreprintCell Biology

Brain cholesterol metabolites cause significant neurodegeneration in human iPSC-derived neurons

Yuqing Feng, Bismoy Mazumder, Tasuku Konno, Ernestine Hui, Marius Brockhoff, Valentina Davì, Meng Lü, Edward Ward, Amberley D. Stephens, Wenyue Dai, Ana Fernández‐Villegas, Giuliana Fusco, Mohsen Ali Asgari, Edward Avezov, Alfonso De Simone, , Gabriele S. Kaminski Schierle

This study shows that 24S-HC and 27-HC, brain cholesterol metabolites, cause neuronal dysfunction in human iPSC-derived neurons by disrupting calcium signaling, organelle function, and alpha-synuclein accumulation.

bioRxiv · Jun 10, 2025 · PreprintNeuroscience