Z. Dong

This study shows that SPOP and ERG mutations in prostate cancer have opposing effects on androgen receptor signaling and therapy response.

This paper develops a nanoparticle-mediated method to enable in vivo analysis of RAS protein activity by delivering a fluorescent GTP analog into cells.

This study develops a non-infectious murine model to study SARS-CoV-2-induced ARDS and CSS, and identifies potential therapeutic agents that alleviate inflammatory symptoms.

This study shows that activating FFA4 reduces airway resistance in mouse models of inflammation and human lung tissue, suggesting it could be a therapeutic target for asthma and COPD.

This study shows that gut dysbiosis reduces liver injury in autophagy-deficient mice through FXR-FGF15 signaling, suggesting caution in antibiotic use during liver disease.

This paper uses deep learning to estimate histological staining intensity from MRI signals, creating virtual histology maps of mouse brains with enhanced sensitivity and specificity.

This study profiles the 2-hydroxyisobutyrylome in common wheat, identifying Khib modification sites and their roles in metabolic pathways and enzyme regulation.

This study develops an artificial sonar system inspired by the brown long-eared bat's vertical sound localization, showing that binaural conformation and orientation are critical for spatial target localization.

This study shows that sgRNA expression level is a major determinant of CRISPRi knockdown efficiency in K562 cells, more impactful than KRAB-dCas9 expression level.

This study investigates how HMGB1 and RAGE promote tumor growth in autophagy-deficient livers by altering the tumor microenvironment and mitochondrial function.

The paper investigates the role of endogenous polyamines and associated genes in paraquat resistance in goosegrass, finding that spermidine levels and specific genes correlate with resistance.

This study shows ionomycin treatment rescues osteoporosis in HPP by restoring Ca2+ influx via ALPL-mediated L-type Ca2+ channel trafficking in BMSCs.

This paper constructs a synthetic inducible promoter by analyzing the 39K promoter of BmNPV and identifies key regulatory regions for virus-inducible activity.