R. Schmid

Microbiota metabolized Bile Acids accelerate Gastroesophageal Adenocarcinoma via FXR inhibition

This study shows that high-fat diets promote GEAC by altering the microbiota-Bile Acid axis and inhibiting FXR, with FXR agonists like OCA slowing disease progression.

plantMASST - Community-driven chemotaxonomic digitization of plants

The paper curates LC-MS/MS data from plant extracts to create a taxonomically focused database for exploring plant-derived molecules.

KRas, in addition to Tp53 is a driver for early carcinogenesis and a molecular target in a mouse model of invasive gastro-esophageal adenocarcinoma

This study identifies KRAS mutation as a driver of invasive gastro-esophageal adenocarcinoma in a mouse model, showing its synergistic role with Tp53 or Rb1 loss and potential as a therapeutic target.

A Taxonomically-informed Mass Spectrometry Search Tool for Microbial Metabolomics Data

MicrobeMASST identifies microbial-derived metabolites and their producers using taxonomically-informed mass spectrometry data without prior knowledge.

Enhanced surface nano-analytics of transient biomolecular processes

This paper develops a lab-on-a-chip method for analyzing biomolecular processes with high sensitivity and single molecule resolution in physiological conditions.

Geometrical frustration of phase-separated domains in Coscinodiscus diatom frustules

The paper investigates the micron-scale organization of Coscinodiscus diatom frustules, revealing competing organizational tendencies that lead to a frustrated triangular lattice with defect accumulation near the center.

The E3 ligase RNF115 regulates phagosome maturation and host response to bacterial infection

This study identifies RNF115 as an E3 ligase that regulates phagosomal maturation and host response to bacterial infection through ubiquitylation.

Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection

The paper investigates the role of lung-resident mesenchymal stem cells in the host response to RSV infection, showing their activation and involvement in antiviral, inflammatory, and repair processes.

The effect of pasture management on fire ant, Solenopsis invicta (Hymenoptera: Formicidae), abundance and the relationship to arthropod community diversity

This study examines how pasture management affects fire ant abundance and arthropod diversity, finding higher fire ant mounds in adaptive multi-paddock pastures but no correlation with arthropod diversity decline.

Native Electrospray-based Metabolomics Enables the Detection of Metal-binding Compounds

The paper introduces a method to detect metal-binding compounds using native electrospray ionization mass spectrometry with metal infusion and molecular networking.

Volume and intramuscular fat content of upper extremity muscles in individuals with chronic hemiparetic stroke

This study quantifies muscle volume and intramuscular fat in stroke survivors, finding reduced muscle volume but no significant increase in intramuscular fat in the paretic limb.