Author

Z. Tu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Evolutionary Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 3 Assay:proteomics· 3 Organism:bacteria (other)· 2 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

A. K. Sharma· 2 shared C. Atkinson· 2 shared G. Cai· 2 shared G. Kramer· 2 shared G. R. Upchurch· 2 shared P. Setlow· 2 shared S. Brul· 2 shared V. Leroy· 2 shared

Activity by Year

2020-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

A. K. Sharma

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Lipoxin A4/FPR2 signaling mitigates ferroptosis of alveolar epithelial cells via NRF2-dependent pathway during lung ischemia-reperfusion injury

D. Manual, V. Leroy, Z. Tu, M. Woolet-Stockton, M. Kamat, T. Garrett, C. Atkinson, G. Cai, G. R. Upchurch, A. K. Sharma

This study shows that LxA4/FPR2 signaling reduces ferroptosis in alveolar epithelial cells via NRF2 activation, protecting against lung ischemia-reperfusion injury.

bioRxiv · Apr 22, 2024Immunology

Non-mechanical disruption of Bacillus subtilis spores allows sensitive and deep characterization of the minimal proteome for resuming a cellular lifestyle.

Y. Huang, A. de Koster, Z. Tu, X. Gao, W. Roseboom, S. Brul, P. Setlow, G. Kramer

This paper introduces a new sample preparation method, SPEED, which improves proteomic analysis of Bacillus subtilis spores by identifying more proteins and enabling differentiation between spore and vegetative cell proteins.

bioRxiv · Mar 8, 2024 · PreprintMicrobiology

Discovery and characterization of chromosomal inversions in the arboviral vector mosquito Aedes aegypti

J. Liang, N. H. Rose, I. I. Brusentsov, V. Lukyanchikova, D. A. Karagodin, Y. Feng, A. A. Yurchenko, M. Sylla, J. Lutomiah, A. Badolo, O. B. Aribodor, D. Ayala, C. G. Acosta, B. W. Alto, N. W. Ahmad, , M. V. Sharakhova

This study identifies chromosomal inversions in Aedes aegypti using Hi-C, revealing geographic distribution patterns and potential roles in host choice and disease transmission.

bioRxiv · Feb 16, 2024 · PreprintEvolutionary Biology

C-di-AMP accumulation disrupts glutathione metabolism and inhibits virulence program expression in Listeria monocytogenes

C. Siletti, M. J. Freeman, Z. Tu, D. M. Stevenson, D. Amador-Noguez, J.-D. Sauer, T. N. Huynh

This study shows that c-di-AMP accumulation in Listeria monocytogenes disrupts glutathione metabolism, leading to reduced virulence gene expression and attenuated pathogenesis.

bioRxiv · Jan 18, 2024 · PreprintMicrobiology

MerTK-dependent efferocytosis by monocytic-MDSCs mediates resolution of post-lung transplant injury

V. Leroy, D. J. Manual Kollareth, Z. Tu, J. Valisno, M. J. Woolet-Stockton, B. Saha, A. Emtiazjoo, M. Rackauskas, L. Moldawer, P. Efron, G. Cai, C. Atkinson, G. R. Upchurch, A. K. Sharma

This study shows that MerTK-dependent efferocytosis by monocytic-MDSCs reduces post-lung transplant ischemia-reperfusion injury.

bioRxiv · Jan 18, 2024 · PreprintImmunology

On the origin and evolution of the mosquito male-determining factor Nix

J. K. Biedler, A. Aryan, Y. Qi, A. Wang, E. O. Martinson, D. Hartman, F. Yang, A. Sharma, K. Morton, M. Potters, C. Chen, S. L. Dobson, G. Ebel, R. C. Kading, S. Paulson, , Z. Tu

This study investigates the origin and evolution of the mosquito male-determining factor Nix across Culicinae subfamily species, finding it originated 133-165 MYA and evolved faster than related factors.

bioRxiv · Dec 7, 2022 · PreprintEvolutionary Biology

High resolution analysis of proteome dynamics during Bacillus subtilis sporulation

Z. Tu, H. Dekker, W. Roseboom, B. Swarge, P. Setlow, S. Brul, G. Kramer

This study uses high-resolution time-lapse proteomics to analyze proteome dynamics during Bacillus subtilis sporulation, identifying co-expressed modules and potential new sporulation-related proteins.

bioRxiv · May 20, 2021Microbiology

Azetidines kill Mycobacterium tuberculosis without detectable resistance by blocking mycolate assembly.

A. B. Lanne, Y. Cui, E. Browne, P. G. E. Craven, N. J. Cundy, N. J. Coltman, K. Dale, A. Feula, J. Frampton, A. Goff, M. A. Hama Salih, X. Lang, X. Li, C. W. Moon, M. Morton, , L. J. Alderwick

The paper identifies azetidine derivatives that kill Mycobacterium tuberculosis without resistance by inhibiting mycolate assembly, showing a novel mode of action and favorable pharmacological profiles.

bioRxiv · Sep 3, 2020 · PreprintMicrobiology