Author

T. N. Huynh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

C. Siletti· 2 shared D. Amador-Noguez· 2 shared D. M. Stevenson· 2 shared J.-D. Sauer· 2 shared A. Fagerlund· 1 shared A. Gmeiner· 1 shared A. H. Okholm· 1 shared A. J. Etter· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

C. Siletti

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

C-di-AMP accumulation disrupts glutathione metabolism and inhibits virulence program expression in Listeria monocytogenes

C. Siletti, M. J. Freeman, Z. Tu, D. M. Stevenson, D. Amador-Noguez, J.-D. Sauer, T. N. Huynh

This study shows that c-di-AMP accumulation in Listeria monocytogenes disrupts glutathione metabolism, leading to reduced virulence gene expression and attenuated pathogenesis.

bioRxiv · Jan 18, 2024 · PreprintMicrobiology

Large-scale phenotypic and genomic characterization of Listeria monocytogenes susceptibility to quaternary ammonium compounds

M. Ivanova, M. Laage Kragh, J. Szarvas, E. S. Tosun, N. F. Holmud, A. Gmeiner, C. F. L. Amar, C. Guldimann, T. N. Huynh, R. Karpiskova, C. R. Garcia, D. Gomez, E. Aboagye, A. J. Etter, P. Centorame, , P. Leekitcharoenphon

This study characterizes QAC susceptibility in 1,671 L. monocytogenes isolates, identifies genetic markers linked to tolerance, and examines global prevalence across 37,897 genomes.

bioRxiv · Sep 7, 2023Microbiology

Synaptopodin is required for efficient intercellular spread by bacterial pathogens

J. M. Vickery, J. D. Toperzer, J. E. Raab, D. J. Hamilton, T. B. Harju, T. N. Huynh, L. Zhou, L. L. Lenz, S. P. Colgan, B. C. Russo

This study identifies synaptopodin as essential for efficient intercellular spread of Shigella flexneri and Listeria monocytogenes by stabilizing actin tails and enabling protrusion formation.

bioRxiv · Apr 25, 2023 · PreprintMicrobiology

Listeria monocytogenes GlmR is an accessory uridyltransferase essential for cytosolic survival and virulence

D. Pensinger, K. V. Gutierrez, H. B. Smith, W. J. B. Vincent, D. M. Stevenson, K. A. Black, K. M. Perez-Medina, J. P. Dillard, K. Y. Rhee, D. Amador-Noguez, T. N. Huynh, J.-D. Sauer

This study identifies GlmR as an accessory uridyltransferase essential for Listeria monocytogenes cytosolic survival and virulence by synthesizing UDP-GlcNAc.

bioRxiv · Oct 27, 2021 · PreprintMicrobiology

NrnA is a linear dinucleotide phosphodiesterase with limited function in cyclic dinucleotide metabolism in Listeria monocytogenes

A. R. Gall, C. Siletti, T. N. Huynh

This study identifies NrnA as a phosphodiesterase in L. monocytogenes that preferentially degrades linear dinucleotides, with limited impact on cyclic dinucleotide levels and no role in regulating their hydrolytic enzymes.

bioRxiv · Apr 21, 2021Microbiology

Polycomb Cbx2 Condensates Assemble through Phase Separation

R. Tatavosian, S. Kent, K. Brown, T. Yao, H. N. Duc, T. N. Huynh, C. Y. Zhen, B. Ma, H. Wang, X. Ren

This study shows that Cbx2 forms condensates via phase separation, which may organize PcG-bound chromatin.

bioRxiv · Nov 12, 2018Biochemistry