Author

J.-D. Sauer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 7 Organism:mouse· 5 Assay:proteomics· 5 Research Focus:cell type annotation· 4 Organism:bacteria (other)· 3 Research Focus:cell signaling & trafficking· 2 Assay:imaging· 2

Frequent Co-Authors

D. Amador-Noguez· 4 shared D. M. Stevenson· 4 shared H. B. Smith· 3 shared A. Huttenlocher· 2 shared C. E. McDougal· 2 shared J. L. Kelliher· 2 shared K. Tweed· 2 shared M. E. Daanen· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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4 shared papersMicrobiology

D. Amador-Noguez

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11 papers

Recent·Most cited

C-di-AMP accumulation disrupts glutathione metabolism and inhibits virulence program expression in Listeria monocytogenes

C. Siletti, M. J. Freeman, Z. Tu, D. M. Stevenson, D. Amador-Noguez, J.-D. Sauer, T. N. Huynh

This study shows that c-di-AMP accumulation in Listeria monocytogenes disrupts glutathione metabolism, leading to reduced virulence gene expression and attenuated pathogenesis.

bioRxiv · Jan 18, 2024 · PreprintMicrobiology

GpsB control of PASTA kinase activity in Listeria monocytogenes influences peptidoglycan synthesis during cell wall stress and cytosolic survival

J. L. Kelliher, M. E. Daanen, J.-D. Sauer

This study shows that GpsB phosphorylation by PrkA regulates peptidoglycan synthesis and cytosolic survival in L. monocytogenes under cell wall stress.

bioRxiv · Jun 12, 2023 · PreprintMicrobiology

A tessellated lymphoid network provides whole-body T cell surveillance in zebrafish

T. F. Robertson, Y. Hou, S. Shen, J. Rindy, J.-D. Sauer, H. Q. Dinh, A. Huttenlocher

This paper identifies a novel lymphoid network in zebrafish that enables whole-body T cell surveillance without lymph nodes, supporting both collective migration and antigen search.

bioRxiv · Jan 17, 2023Immunology

Listeria monocytogenes requires DHNA-dependent intracellular redox homeostasis facilitated by Ndh2 for survival and virulence

H. B. Smith, K. Lee, D. M. Stevenson, D. Amador-Noguez, J.-D. Sauer

This study shows that Listeria monocytogenes uses DHNA-dependent redox homeostasis via Ndh2 for survival and virulence, independent of respiration.

bioRxiv · Jan 13, 2023 · PreprintMicrobiology

Type I Interferon Signaling on Antigen-Presenting Cells Blunts Cell-Mediated Immunity Toward Listeria monocytogenes

J.-D. Sauer, Z. T. Morrow

This study shows that reducing type I interferon signaling enhances CD8+ T-cell responses to Listeria monocytogenes vaccination by increasing memory precursor T-cells without compromising short-lived effectors.

bioRxiv · Dec 2, 2022 · PreprintImmunology

Listeria monocytogenes GlmR is an accessory uridyltransferase essential for cytosolic survival and virulence

D. Pensinger, K. V. Gutierrez, H. B. Smith, W. J. B. Vincent, D. M. Stevenson, K. A. Black, K. M. Perez-Medina, J. P. Dillard, K. Y. Rhee, D. Amador-Noguez, T. N. Huynh, J.-D. Sauer

This study identifies GlmR as an accessory uridyltransferase essential for Listeria monocytogenes cytosolic survival and virulence by synthesizing UDP-GlcNAc.

bioRxiv · Oct 27, 2021 · PreprintMicrobiology

PASTA kinase-dependent control of peptidoglycan synthesis via ReoM is required for cell wall stress responses, cytosolic survival, and virulence in Listeria monocytogenes

J. L. Kelliher, C. M. Grunenwald, R. R. Abrahams, M. E. Daanen, C. I. Lew, W. E. Rose, J.-D. Sauer

This study identifies ReoM as a phosphosubstrate of PrkA in Listeria monocytogenes, showing its role in peptidoglycan synthesis and virulence during cell wall stress.

bioRxiv · Aug 20, 2021Microbiology

Prostaglandin E2 induction by cytosolic Listeria monocytogenes in phagocytes is necessary for optimal T-cell priming

C. E. McDougal, Z. T. Morrow, S. Kim, D. Carter, D. M. Stevenson, D. Amador-Noguez, M. J. Miller, J.-D. Sauer

This study identifies PGE2 production via COX-2 as a cytosol-dependent innate immune response critical for CD8+ T-cell priming against L. monocytogenes.

bioRxiv · Mar 23, 2021 · PreprintImmunology

Listeria monocytogenes MenI encodes a DHNA-CoA thioesterase necessary for menaquinone biosynthesis, cytosolic survival, and virulence

H. B. Smith, T. L. Li, M. K. Liao, G. Y. Chen, Z. Guo, J.-D. Sauer

bioRxiv · Dec 21, 2020Microbiology

In vivo fluorescence lifetime imaging captures metabolic changes in macrophages during wound responses in zebrafish

V. Miskolci, K. Tweed, M. Lasarev, E. C. Britt, C. E. McDougal, A. J. Walsh, J. Fan, J.-D. Sauer, M. Skala, A. Huttenlocher

This paper uses in vivo FLIM to track metabolic changes in macrophages during wound responses in zebrafish, showing dynamic shifts in NAD(P)H and FAD redox ratios.

bioRxiv · Jun 16, 2020Immunology

Nano-Emulsion Adjuvant Enhances Cross-presentation by Lipid Body Formation Independent of Glycolysis

M. Suresh, W. Lee, B. Kingstad-Bakke, B. Paulson, A. Larsen, K. Overmyer, C. Marinaik, K. Dull, R. Toy, G. Vogel, K. Mueller, K. Tweed, A. Walsh, J. Russell, K. Saha, , K. Roy

This study shows that the nano-emulsion adjuvant Adjuplex enhances cross-presentation in dendritic cells without requiring glycolysis, relying instead on lipid body formation and ROS.

bioRxiv · May 8, 2020 · PreprintImmunology