Z. Yan

This study shows that SARS-CoV-2 infection of polarized human airway epithelium is long-lasting with recurring replication peaks every 7-10 days and requires a high viral load.

The paper reports the cryo-EM structure of human NALCN with FAM155A, revealing interactions and ion-binding sites that inform Na+ permeation and disease mechanisms.

This study identifies gut microbiota changes and their associations with cerebral cortex and cerebrovascular abnormalities in human mild traumatic brain injury.

The paper identifies a 382-nt deletion in SARS-CoV-2 ORF8 from Singapore patients, which enhances N gene transcription and may contribute to viral attenuation.

This study shows that reducing SIRT2 rescues GARS-induced neuropathy in a Drosophila model by restoring acetylated tubulin levels and axonal transport.

This paper reveals the atomistic mechanism of NompC channel opening under intracellular compression using simulations and experiments, showing force transmission through ankyrin repeats and linker helices to the TRP domain.

This study identifies two benzophenanthridine alkaloids from Corydalis longicalcarata rhizomes with anti-mitotic and polyploidy-inducing activities through a phenotypic screen of medicinal plant extracts.

This study analyzes 2,152 antibody repertoires to identify key features of B cell biology, revealing gene usage patterns, sex preferences, and mutability mechanisms in the antibody repertoire.

This paper demonstrates PhyloNet's functionalities for analyzing phylogenetic networks using simulated data and provides recommendations for data analysis and interpretation.

This study presents methods to detect dynamic, partially occupied protein conformations in crystals using anomalous scattering signals with low occupancy.

This paper develops a chemically defined, albumin-free method to produce enucleated red blood cells from human iPSCs, achieving up to 50% enucleated cell yield.

The paper shows OxyR in E. coli detects reactive sulfane sulfur and activates genes for its removal via thioredoxin and glutaredoxin.

The paper examines evolutionary rate correlations between mitochondrial and nuclear-encoded mitochondrial proteins in insects, identifying potential new mitochondrial function candidates.