Delineating the Transcriptional and Phenotypic Impact from Biotherapeutic Glycoengineering
Haining Li, Austin W.T. Chiang, Vahid Gazestani, Bokan Bao, Shangzhong Li, P Ménard, Johnny Arnsdorf, Zulfiya Sukhova, Sara Petersen Bjørn, Karen Kathrine Brøndum, Anders Holmgaard Hansen, Sanne Schoffelen, Bjørn Gunnar Rude Voldborg, Nathan E. Lewis
The paper investigates the phenotypic and transcriptional effects of glycoengineering in CHO cells, identifying distinct clusters and molecular mechanisms associated with different glycosyltransferase modifications.
bioRxiv · Apr 22, 2026 · PreprintSynthetic Biology