Author

Matthias Miederer

German Cancer Research CenterORCID 0000-0001-5075-5995Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

Jürgen Brück· 2 shared Alexander MuikiD· 1 shared Aniello FedericoiD· 1 shared Aron Kwiatkowski· 1 shared Ayline KübleriD· 1 shared Benedikt KlaseniD· 1 shared Dominik SchauenburgiD· 1 shared Eliana StanganelloiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

Jürgen Brück

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2 papers

Recent·Most cited

Lung-targeted cytokine-coding RNA-lipoplexes induce T and NK cell-mediated anti-tumor immune response

Ayline Kübler, Sophie-Christin Linkenbach, Fulvia Vascotto, Elif Diken, Özlem Akilli‐Öztürk, Eliana Stanganello, Aniello Federico, Sina Fellermeier-Kopf, Alexander Muik, Friederike Gieseke, M Suchan, Ferdia Bates, Kaushik Thanki, Hossam Hefesha, Isaac Hernan Esparza Borquez, , Uğur Şahin

This study shows that lung-targeted cytokine RNA-lipoplexes enhance anti-tumor immunity by activating T and NK cells and reducing Tregs, with efficacy in murine models and human lung tumor cultures.

bioRxiv · May 11, 2026 · PreprintImmunology

Non-invasive visualization of pH changes within the tumor-micro-environment by positron emission tomography

Jürgen Brück, Dominik Schauenburg, Seah Ling Kuan, Simeon Göttert, Benedikt Klasen, Veronika Frommberger, Kazem Ebadi Jalal, Nabil Boui, Aron Kwiatkowski, Lisa Schake, Tobias Bopp, Toszka Bohn, Tanja Weil, M. Schreckenberger, Matthias Miederer

This paper develops a PET-based method to visualize pH changes in the tumor microenvironment using [18F]FDG-4MBA, showing it can detect small pH differences in different tumors in the same mouse.

EJNMMI Research · Feb 5, 2026Peer-reviewedCancer Biology