Jean Chemin

Endothelin Signaling via EDNRB receptor Reduces Proliferation and Promotes Proneural-to-Mesenchymal Transition in Gliomas

This study identifies endothelin signaling via EDNRB as a regulator of glioma cell proliferation and proneural-to-mesenchymal transition, with distinct receptor expression and functional roles in different tumor subtypes.

Facilitation of Cav3.2 channel gating in pain pathways reveals a novel mechanism of serum-induced hyperalgesia

The paper identifies a novel mechanism of serum-induced hyperalgesia through the facilitation of Cav3.2 channel gating by the peptide albumin (1-26).

Functional expression and sex dimorphism of the T-type Cav3.2 Calcium Channel in human DRG Neurons

The paper demonstrates that Cav3.2 calcium channels are expressed in human DRG neurons and exhibit sex dimorphism, supporting their role in pain mechanisms.

T-type calcium channels participate in intrinsic and synaptic activity of PKCγ neurons of the dorsal horn of the spinal cord during chronic pain

This study investigates the role of T-type calcium channel Cav3.2 in PKCγ neurons of the spinal dorsal horn during chronic pain, showing its involvement in synaptic and intrinsic activity changes but not in firing properties.

Voltage tunes mGlu5 receptor function, impacting synaptic transmission

The paper investigates how voltage affects mGlu5 receptor function and its impact on synaptic transmission in neurons.

The impact of C-Tactile Low threshold mechanoreceptors on affective touch and social interactions in mice.

This study shows that C-LTMRs in mice influence social behavior and affective touch, with their dysfunction leading to social isolation and increased excitability promoting pro-social interactions.