Author

Arthur M. Mandelin

Northwestern UniversityORCID 0000-0001-5669-7917Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Immunology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:scRNA-seq· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

Adam T. Chicoine· 5 shared Amit LakhanpaliD· 5 shared Andrew D. FileriD· 5 shared Christopher T. RitchliniD· 5 shared Costantino PitzalisiD· 5 shared Dana E. OrangeiD· 5 shared Diane Horowitz· 5 shared Edward F. DiCarloiD· 5 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

Adam T. Chicoine

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

SPP1hi macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium

Ian Mantel, Haoxuan Zhang, Juan Vargas, Ce Gao, Hope A. Townsend, Richard D. Bell, Amit Lakhanpal, Miriam R. Fein, Accelerating Medicines Partnership: RA/SLE Network, Thomas M. Norman, Dana E. Orange, Daniel C. Ramirez, Edward F. DiCarlo, Susan M. Goodman, Melanie H. Smith, , Thomas Eisenhaure

SPP1hi macrophages in RA synovial fibrin deposits promote tissue hyperplasia.

Science Translational Medicine · Jun 24, 2026Peer-reviewedImmunology

Granzyme K drives a newly-intentified pathway of complement activation

C. A. Donado, Erin Theisen, Fan Zhang, Aparna Nathan, Madison L. Fairfield, Karishma Vijay Rupani, Dominique Jones, Kellsey Johannes, Accelerating Medicines Partnership RA/SLE Network, Jennifer Albrecht, Jennifer H. Anolik, William A. Apruzzese, Jennifer L. Barnas, Joan M. Bathon, Ami Ben‐Artzi, , Michael B. Brenner

This study identifies granzyme K as a driver of a novel complement activation pathway independent of classical, lectin, or alternative pathways.

Nature · Feb 6, 2025Peer-reviewedImmunology

Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles

Saori Sakaue, Kathryn Weinand, Shakson Isaac, Kushal K. Dey, Karthik A. Jagadeesh, Masahiro Kanai, Gerald F. M. Watts, Zhu Zhu, Accelerating Medicines Partnership® RA/SLE Program and Network, Jennifer Albrecht, Jennifer H. Anolik, William A. Apruzzese, Nirmal K. Banda, Jennifer L. Barnas, Joan M. Bathon, , Soumya Raychaudhuri

The paper develops SCENT, a method to create cell-type-specific enhancer-gene maps from single-cell multimodal data, identifying causal variants and genes for diseases.

Nature Genetics · Apr 1, 2024Peer-reviewedGenetic & Genomic Medicine

Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution

Joyce B. Kang, Amber Z. Shen, Saisriram Gurajala, Aparna Nathan, Laurie Rumker, Vitor R. C. Aguiar, Cristian Valencia, Kaitlyn A. Lagattuta, Fan Zhang, Anna Helena Jonsson, Seyhan Yazar, José Alquicira-Hernández, Hamed Khalili, Ashwin N. Ananthakrishnan, Karthik A. Jagadeesh, , Joseph E. Powell

The paper maps cell-type-specific eQTLs for HLA genes across multiple tissues and identifies dynamic regulation of HLA-DQ genes in immune cells.

Nature Genetics · Nov 30, 2023Peer-reviewedGenetic & Genomic Medicine

Cellular deconstruction of inflamed synovium defines diverse inflammatory phenotypes in rheumatoid arthritis

Fan Zhang, Anna Helena Jonsson, Aparna Nathan, Kevin Wei, Nghia Millard, Qian Xiao, María Gutiérrez‐Arcelus, William A. Apruzzese, Gerald F. M. Watts, Dana Weisenfeld, Joyce B. Kang, Laurie Rumker, Joseph Mears, Kamil Slowikowski, Kathryn Weinand, , Zhu Zhu

The paper deconstructs RA synovium using single-cell data to identify six cell type abundance phenotypes associated with distinct inflammatory states.

bioRxiv · Feb 25, 2022 · PreprintGenomics