Christopher T. Ritchlin

SPP1hi macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium

SPP1hi macrophages in RA synovial fibrin deposits promote tissue hyperplasia.

Automated Joint Space Detection Improves Bone Segmentation Accuracy

This paper introduces a deep learning model for automated joint space detection in micro-CT images of mouse paws, significantly improving segmentation accuracy compared to semi-automated methods.

The Function of Efhd1+ Telocytes in the Synovial Lymphatic System and Inflammatory-Erosive Arthritis

This study identifies Efhd1+ telocytes in the synovial lymphatic system and shows their role in lymphatic drainage and protection against inflammatory-erosive arthritis.

Granzyme K drives a newly-intentified pathway of complement activation

This study identifies granzyme K as a driver of a novel complement activation pathway independent of classical, lectin, or alternative pathways.

Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles

The paper develops SCENT, a method to create cell-type-specific enhancer-gene maps from single-cell multimodal data, identifying causal variants and genes for diseases.

Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution

The paper maps cell-type-specific eQTLs for HLA genes across multiple tissues and identifies dynamic regulation of HLA-DQ genes in immune cells.

Cellular deconstruction of inflamed synovium defines diverse inflammatory phenotypes in rheumatoid arthritis

The paper deconstructs RA synovium using single-cell data to identify six cell type abundance phenotypes associated with distinct inflammatory states.