Sebastian Wiese

This study identifies human histone H1.2 peptide as an antimicrobial agent against Pseudomonas aeruginosa, showing dose- and pH-dependent growth inhibition without cytotoxicity to mammalian cells.

The paper identifies Laudanosine as an inhibitor of TPC2-dependent viral entry, effective against Ebola and related viruses without cytotoxicity.

The paper shows that ribosomal error-rate adapts in human aging models but not in mouse models, involving ER-stress signaling and Alzheimer's proteins.

This study develops a murine model of trauma-related acute kidney injury and identifies early renal stress responses and inflammatory changes.

This paper identifies Trypstatin, a Kunitz-type protease inhibitor that inhibits TMPRSS2 and related proteases, showing broad-spectrum antiviral activity against SARS-CoV-2, influenza, and other respiratory viruses.

This study identifies Retinol Binding Protein 4 (RBP4) as a natural activator of latent HIV-1 through JAK/STAT5 and JNK pathways, offering a new strategy for reactivating viral reservoirs.

This study identifies ARF1 as a negative regulator of cGAS-STING signaling, showing it prevents type I IFN induction by regulating STING activation and recycling.

The paper identifies SEPT9's interaction network using quantitative proteomics, revealing its role in vesicle transport and actin stress fiber attachment.