Laudanosine restricts Ebola virus entry by targeting TPC2-dependent endolysosomal trafficking
Tom Seitz, Julian Köngeter, Susanne Klute, Franziska Kraft, Denise Christine Clesle, Lily Tschampel, Nico Preising, Armando Rodríguez Alfonso, Sebastian Wiese, Ludger Ständker, Christoph Jung, Timo Jacob, Janet Köhler, Gilbert Weidinger, Nadine Biedenkopf, , Fabian Zech
The paper identifies Laudanosine as an inhibitor of TPC2-dependent viral entry, effective against Ebola and related viruses without cytotoxicity.
bioRxiv · Jun 18, 2026 · PreprintMicrobiology