Sandra Blaess

A new conditional mouse model for Cre-mediated restoration of Hprt1 expression during brain development

This paper introduces a conditional Hprt1 mouse model to study the effects of gene restoration during brain development and demonstrates its utility in understanding reversibility in genetic disorders.

Basolateral amygdala dopamine signals behavioural salience across exploration and learning

This study shows dopamine in the basolateral amygdala increases during exploratory actions and tracks cue relevance in learning, suggesting it signals behaviorally relevant moments.

A human developmental and adult brain atlas benchmarks dopaminergic stem cell models and cell therapy candidates

The paper benchmarks dopaminergic stem cell models and cell therapy candidates using a human brain atlas to identify off-target populations and lineage plasticity.

Targeting aberrant dendritic integration to treat cognitive comorbidities of epilepsy

The paper identifies a Na+ channel-dependent mechanism in hippocampal dendrites that contributes to spatial memory deficits in epilepsy and shows that targeting Nav1.3 channels can reverse these deficits.

The transcription factor BCL11A defines a distinctive subset of dopamine neurons in the developing and adult midbrain

This study identifies BCL11A as a defining transcription factor for a distinct subset of midbrain dopamine neurons, showing their vulnerability to Parkinson's disease and developmental roles in motor function.

Formation of the substantia nigra requires Reelin-mediated fast, laterally-directed migration of dopaminergic neurons

This study identifies Reelin's role in promoting fast, laterally-directed migration of midbrain dopaminergic neurons through stabilization of leading processes and induction of bipolar morphology.