Author

Núria Setó‐Salvia

UCL Queen Square Institute of NeurologyORCID 0000-0002-3753-0027Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Approach:experimental assay· 1

Frequent Co-Authors

Rickie PataniiD· 2 shared Aaron Z. WageniD· 1 shared Ali E. GhareebiD· 1 shared Argyro AlatzaiD· 1 shared Benjamin E. ClarkeiD· 1 shared Benjamin GaletiD· 1 shared Charles ArberiD· 1 shared Christina E. ToomeyiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Rickie PataniORCID

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2 papers

Recent·Most cited

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis

Oliver Jonathan Ziff, Gustavo Morrone Parfitt, Sarah Jolly, Jackie M. Casey, Lucy Granat, Satinder K. Samra, Núria Setó‐Salvia, Argyro Alatza, Leela Phadke, Benjamin Galet, Philippe Ravassard, Marie‐Claude Potier, John Hardy, Dervis A. M. Salih, Paul John Whiting, , Charles Arber

This study shows that PSEN1 mutations disrupt regulated intramembrane proteolysis in astrocytes, leading to enhanced inflammatory responses and contributing to familial Alzheimer's disease progression.

Molecular Neurodegeneration · Jun 20, 2025Peer-reviewedNeuroscience

Astrocytic RNA editing regulates the host immune response to alpha-synuclein

Karishma D’Sa, Minee L. Choi, Aaron Z. Wagen, Núria Setó‐Salvia, Olga Kopach, James R. Evans, Margarida Rodrigues, Patricia Lopez-Garcia, Joanne Lachica, Benjamin E. Clarke, Jaijeet Singh, Ali E. Ghareeb, James Bayne, Melissa Grant‐Peters, Sonia García-Ruiz, , Mina Ryten

The paper shows that astrocytic RNA editing via ADAR1 modulates immune responses to alpha-synuclein, contributing to neuroinflammation in Parkinson's disease.

Science Advances · Apr 11, 2025Peer-reviewedNeuroscience